Project Details
Description
1. To evaluate symptoms of gastrointestinal dysfunction in people with PWP;
2. To identify and describe PWP oral health status;
3. To study the PwP nasal, oral and fecal microbiota;
4. To confirm the presence of, and to characterize, alpha-synuclein aggregates in gut biopsy specimens of PWP;
5. To study the PwP microbiome in gut biopsy;
6. In PwP, to correlate the burden of gastrointestinal dysfunction, oral health problems, microbiota dysbiosis and gut alpha-synuclein aggregates with disease duration, severity, motor and non-motor features, ongoing treatment, depression and QoL.
2. To identify and describe PWP oral health status;
3. To study the PwP nasal, oral and fecal microbiota;
4. To confirm the presence of, and to characterize, alpha-synuclein aggregates in gut biopsy specimens of PWP;
5. To study the PwP microbiome in gut biopsy;
6. In PwP, to correlate the burden of gastrointestinal dysfunction, oral health problems, microbiota dysbiosis and gut alpha-synuclein aggregates with disease duration, severity, motor and non-motor features, ongoing treatment, depression and QoL.
| Acronym | GutSPark |
|---|---|
| Status | Finished |
| Effective start/end date | 31/01/22 → 31/01/24 |
UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This project contributes towards the following SDG(s):
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