A spontaneous ovarian teratoma in an FVB/n female mouse: Case report and literature review

Paula Alexandra Martins de Oliveira; Ana I. Faustino-Rocha; Rui M.Gil da Costa; Elisabete Nascimento Gonçalves; Ana Margarida Calado; Catarina Jota Baptista; Adelina Gama; Fernanda Seixas

doi:10.5455/OVJ.2023.v13.i9.19

A spontaneous ovarian teratoma in an FVB/n female mouse: Case report and literature review

Paula Alexandra Martins de Oliveira
, Ana I. Faustino-Rocha
, Rui M.Gil da Costa
, Elisabete Nascimento Gonçalves
, Ana Margarida Calado
, Catarina Jota Baptista
, Adelina Gama
, Fernanda Seixas

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

Background: Teratomas are rare types of germ cell neoplasms composed of various differentiated or undifferentiated tissues. Case Description: A 25-week-old female control FVB /n mouse in a 4-week toxicity study presented abdominal distension and poor body condition. It was euthanized, and the necropsy examination revealed a large mass connected to the tip of the right uterine horn, occupying the entire abdominal cavity. Microscopically, this mass showed areas of epidermal differentiation, with laminated keratin and sebaceous glands, differentiation into respiratory and digestive epithelium, cartilage, bone, and extensive areas of differentiation into the nervous tissue, being classified as an ovarian teratoma. Conclusion: As far as authors know, the occurrence of ovarian teratomas in the FVB/n mouse strain has never been previously described.

Original language	English
Pages (from-to)	1223-1227
Number of pages	5
Journal	Open Veterinary Journal
Volume	13
Issue number	9
DOIs	https://doi.org/10.5455/OVJ.2023.v13.i9.19
Publication status	Published - 2023
Externally published	Yes

Keywords

Mouse
Ovary
Rodent
Teratoma

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10.5455/OVJ.2023.v13.i9.19

Cite this

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title = "A spontaneous ovarian teratoma in an FVB/n female mouse: Case report and literature review",

abstract = "Background: Teratomas are rare types of germ cell neoplasms composed of various differentiated or undifferentiated tissues. Case Description: A 25-week-old female control FVB /n mouse in a 4-week toxicity study presented abdominal distension and poor body condition. It was euthanized, and the necropsy examination revealed a large mass connected to the tip of the right uterine horn, occupying the entire abdominal cavity. Microscopically, this mass showed areas of epidermal differentiation, with laminated keratin and sebaceous glands, differentiation into respiratory and digestive epithelium, cartilage, bone, and extensive areas of differentiation into the nervous tissue, being classified as an ovarian teratoma. Conclusion: As far as authors know, the occurrence of ovarian teratomas in the FVB/n mouse strain has never been previously described.",

keywords = "Mouse, Ovary, Rodent, Teratoma",

author = "\{de Oliveira\}, \{Paula Alexandra Martins\} and Faustino-Rocha, \{Ana I.\} and \{da Costa\}, \{Rui M.Gil\} and Gon{\c c}alves, \{Elisabete Nascimento\} and Calado, \{Ana Margarida\} and Baptista, \{Catarina Jota\} and Adelina Gama and Fernanda Seixas",

year = "2023",

doi = "10.5455/OVJ.2023.v13.i9.19",

language = "English",

volume = "13",

pages = "1223--1227",

journal = "Open Veterinary Journal",

issn = "2226-4485",

publisher = "Faculty of Veterinary Medicine, University of Tripoli",

number = "9",

}

TY - JOUR

T1 - A spontaneous ovarian teratoma in an FVB/n female mouse

T2 - Case report and literature review

AU - de Oliveira, Paula Alexandra Martins

AU - Faustino-Rocha, Ana I.

AU - da Costa, Rui M.Gil

AU - Gonçalves, Elisabete Nascimento

AU - Calado, Ana Margarida

AU - Baptista, Catarina Jota

AU - Gama, Adelina

AU - Seixas, Fernanda

PY - 2023

Y1 - 2023

N2 - Background: Teratomas are rare types of germ cell neoplasms composed of various differentiated or undifferentiated tissues. Case Description: A 25-week-old female control FVB /n mouse in a 4-week toxicity study presented abdominal distension and poor body condition. It was euthanized, and the necropsy examination revealed a large mass connected to the tip of the right uterine horn, occupying the entire abdominal cavity. Microscopically, this mass showed areas of epidermal differentiation, with laminated keratin and sebaceous glands, differentiation into respiratory and digestive epithelium, cartilage, bone, and extensive areas of differentiation into the nervous tissue, being classified as an ovarian teratoma. Conclusion: As far as authors know, the occurrence of ovarian teratomas in the FVB/n mouse strain has never been previously described.

AB - Background: Teratomas are rare types of germ cell neoplasms composed of various differentiated or undifferentiated tissues. Case Description: A 25-week-old female control FVB /n mouse in a 4-week toxicity study presented abdominal distension and poor body condition. It was euthanized, and the necropsy examination revealed a large mass connected to the tip of the right uterine horn, occupying the entire abdominal cavity. Microscopically, this mass showed areas of epidermal differentiation, with laminated keratin and sebaceous glands, differentiation into respiratory and digestive epithelium, cartilage, bone, and extensive areas of differentiation into the nervous tissue, being classified as an ovarian teratoma. Conclusion: As far as authors know, the occurrence of ovarian teratomas in the FVB/n mouse strain has never been previously described.

KW - Mouse

KW - Ovary

KW - Rodent

KW - Teratoma

UR - https://www.scopus.com/pages/publications/85174257124

U2 - 10.5455/OVJ.2023.v13.i9.19

DO - 10.5455/OVJ.2023.v13.i9.19

M3 - Article

C2 - 37842105

AN - SCOPUS:85174257124

SN - 2226-4485

VL - 13

SP - 1223

EP - 1227

JO - Open Veterinary Journal

JF - Open Veterinary Journal

IS - 9

ER -

A spontaneous ovarian teratoma in an FVB/n female mouse: Case report and literature review

Abstract

Keywords

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