TY - JOUR
T1 - American Academy of Periodontology best evidence consensus statement on the use of biologics in clinical practice
AU - Avila-Ortiz, Gustavo
AU - Ambruster, Jeanne
AU - Barootchi, Shayan
AU - Chambrone, Leandro
AU - Chen, Chia Yu
AU - Dixon, Douglas R.
AU - Geisinger, Maria L.
AU - Giannobile, William V.
AU - Goss, Katie
AU - Gunsolley, John C.
AU - Heard, Rick H.
AU - Kim, David M.
AU - Mandelaris, George A.
AU - Monje, Alberto
AU - Nevins, Marc L.
AU - Palaiologou-Gallis, Angela
AU - Rosen, Paul S.
AU - Scheyer, E. Todd
AU - Suarez-Lopez del Amo, Fernando
AU - Tavelli, Lorenzo
AU - Velasquez, Diego
AU - Wang, Hom Lay
AU - Mealey, Brian L.
N1 - Publisher Copyright:
© 2022 The Authors. Journal of Periodontology published by Wiley Periodicals LLC on behalf of American Academy of Periodontology.
PY - 2022/12
Y1 - 2022/12
N2 - A biologic is a therapeutic agent with biological activity that is administered to achieve an enhanced regenerative or reparative effect. The use of biologics has progressively become a core component of contemporary periodontal practice. However, some questions remain about their safety, indications, and effectiveness in specific clinical scenarios. Given their availability for routine clinical use and the existing amount of related evidence, the goal of this American Academy of Periodontology (AAP) best evidence consensus (BEC) was to provide a state-of-the-art, evidence-based perspective on the therapeutic application of autologous blood-derived products (ABPs), enamel matrix derivative (EMD), recombinant human platelet-derived growth factor BB (rhPDGF-BB), and recombinant human bone morphogenetic protein 2 (rhBMP-2). A panel of experts with extensive knowledge on the science and clinical application of biologics was convened. Three systematic reviews covering the areas of periodontal plastic surgery, treatment of infrabony defects, and alveolar ridge preservation/reconstruction and implant site development were conducted a priori and provided the foundation for the deliberations. The expert panel debated the merits of published data and exchanged experiential information to formulate evidence-based consensus statements and recommendations for clinical practice and future research. Based on an analysis of the current evidence and expert opinion, the panel concluded that the appropriate use of biologics in periodontal practice is generally safe and provides added benefits to conventional treatment approaches. However, therapeutic benefits and risks range based on the specific biologics used as well as patient-related local and systemic factors. Given the limited evidence available for some indications (e.g., gingival augmentation therapy, alveolar ridge preservation/reconstruction, and implant site development), future clinical studies that can expand the knowledge base on the clinical use of biologics in periodontal practice are warranted.
AB - A biologic is a therapeutic agent with biological activity that is administered to achieve an enhanced regenerative or reparative effect. The use of biologics has progressively become a core component of contemporary periodontal practice. However, some questions remain about their safety, indications, and effectiveness in specific clinical scenarios. Given their availability for routine clinical use and the existing amount of related evidence, the goal of this American Academy of Periodontology (AAP) best evidence consensus (BEC) was to provide a state-of-the-art, evidence-based perspective on the therapeutic application of autologous blood-derived products (ABPs), enamel matrix derivative (EMD), recombinant human platelet-derived growth factor BB (rhPDGF-BB), and recombinant human bone morphogenetic protein 2 (rhBMP-2). A panel of experts with extensive knowledge on the science and clinical application of biologics was convened. Three systematic reviews covering the areas of periodontal plastic surgery, treatment of infrabony defects, and alveolar ridge preservation/reconstruction and implant site development were conducted a priori and provided the foundation for the deliberations. The expert panel debated the merits of published data and exchanged experiential information to formulate evidence-based consensus statements and recommendations for clinical practice and future research. Based on an analysis of the current evidence and expert opinion, the panel concluded that the appropriate use of biologics in periodontal practice is generally safe and provides added benefits to conventional treatment approaches. However, therapeutic benefits and risks range based on the specific biologics used as well as patient-related local and systemic factors. Given the limited evidence available for some indications (e.g., gingival augmentation therapy, alveolar ridge preservation/reconstruction, and implant site development), future clinical studies that can expand the knowledge base on the clinical use of biologics in periodontal practice are warranted.
KW - alveolar ridge preservation
KW - biologics
KW - implant site development
KW - periodontal plastic surgery
KW - periodontal regeneration
KW - periodontal therapy
UR - http://www.scopus.com/inward/record.url?scp=85140373205&partnerID=8YFLogxK
U2 - 10.1002/JPER.22-0361
DO - 10.1002/JPER.22-0361
M3 - Article
C2 - 36279407
AN - SCOPUS:85140373205
SN - 0022-3492
VL - 93
SP - 1763
EP - 1770
JO - Journal of Periodontology
JF - Journal of Periodontology
IS - 12
ER -