TY - JOUR
T1 - Antibacterial activity of naphthyl derived bis-(3-hydroxy-4-pyridinonate) copper(II) complexes against multidrug-resistant bacteria
AU - Leite, Andreia
AU - Bessa, Lucinda J.
AU - Silva, Ana M.G.
AU - Gameiro, Paula
AU - de Castro, Baltazar
AU - Rangel, Maria
N1 - Publisher Copyright:
© 2019 Elsevier Inc.
PY - 2019/8
Y1 - 2019/8
N2 - In this work, we report the synthesis and characterization of three novel copper(II) complexes of naphthyl derived 3-hydroxy-4-pyridinone chelators. Their antibacterial activity against several Gram-positive and Gram-negative reference strains and multidrug-resistant clinical isolates was assessed through determination of the minimum inhibitory concentration (MIC). The complex Cu(naph1pp) 2 shows the highest antibacterial activity, including against multidrug-resistant isolates, nonetheless, being more active against Gram-positive than Gram-negative bacteria. Cu(naph1pp) 2 was further explored in combinatorial tests with ciprofloxacin against methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus faecalis (VRE). The combination of Cu(naph1pp) 2 and ciprofloxacin is considered additive, i.e., the effect of the two compounds combined is stronger than that of the individual compounds in the equivalent concentration.
AB - In this work, we report the synthesis and characterization of three novel copper(II) complexes of naphthyl derived 3-hydroxy-4-pyridinone chelators. Their antibacterial activity against several Gram-positive and Gram-negative reference strains and multidrug-resistant clinical isolates was assessed through determination of the minimum inhibitory concentration (MIC). The complex Cu(naph1pp) 2 shows the highest antibacterial activity, including against multidrug-resistant isolates, nonetheless, being more active against Gram-positive than Gram-negative bacteria. Cu(naph1pp) 2 was further explored in combinatorial tests with ciprofloxacin against methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus faecalis (VRE). The combination of Cu(naph1pp) 2 and ciprofloxacin is considered additive, i.e., the effect of the two compounds combined is stronger than that of the individual compounds in the equivalent concentration.
KW - 3-hydroxy-4-pyridinones
KW - Antibacterial activity
KW - Copper(II) complexes
KW - Multidrug-resistant isolates
KW - Synergy with ciprofloxacin
UR - http://www.scopus.com/inward/record.url?scp=85065442743&partnerID=8YFLogxK
U2 - 10.1016/j.jinorgbio.2019.110704
DO - 10.1016/j.jinorgbio.2019.110704
M3 - Article
C2 - 31078872
AN - SCOPUS:85065442743
SN - 0162-0134
VL - 197
JO - Journal of Inorganic Biochemistry
JF - Journal of Inorganic Biochemistry
M1 - 110704
ER -
