Antibacterial activity of naphthyl derived bis-(3-hydroxy-4-pyridinonate) copper(II) complexes against multidrug-resistant bacteria

Andreia Leite; Lucinda J. Bessa; Ana M.G. Silva; Paula Gameiro; Baltazar de Castro; Maria Rangel

doi:10.1016/j.jinorgbio.2019.110704

Antibacterial activity of naphthyl derived bis-(3-hydroxy-4-pyridinonate) copper(II) complexes against multidrug-resistant bacteria

Andreia Leite
, Lucinda J. Bessa
, Ana M.G. Silva
, Paula Gameiro
, Baltazar de Castro
, Maria Rangel

Research output: Contribution to journal › Article › peer-review

22 Citations (Scopus)

Abstract

In this work, we report the synthesis and characterization of three novel copper(II) complexes of naphthyl derived 3-hydroxy-4-pyridinone chelators. Their antibacterial activity against several Gram-positive and Gram-negative reference strains and multidrug-resistant clinical isolates was assessed through determination of the minimum inhibitory concentration (MIC). The complex Cu(naph1pp) ₂ shows the highest antibacterial activity, including against multidrug-resistant isolates, nonetheless, being more active against Gram-positive than Gram-negative bacteria. Cu(naph1pp) ₂ was further explored in combinatorial tests with ciprofloxacin against methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus faecalis (VRE). The combination of Cu(naph1pp) ₂ and ciprofloxacin is considered additive, i.e., the effect of the two compounds combined is stronger than that of the individual compounds in the equivalent concentration.

Original language	English
Article number	110704
Journal	Journal of Inorganic Biochemistry
Volume	197
DOIs	https://doi.org/10.1016/j.jinorgbio.2019.110704
Publication status	Published - Aug 2019
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

3-hydroxy-4-pyridinones
Antibacterial activity
Copper(II) complexes
Multidrug-resistant isolates
Synergy with ciprofloxacin

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10.1016/j.jinorgbio.2019.110704

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@article{c368b956b8e546e2a8e7ec9033214980,

title = "Antibacterial activity of naphthyl derived bis-(3-hydroxy-4-pyridinonate) copper(II) complexes against multidrug-resistant bacteria",

abstract = " In this work, we report the synthesis and characterization of three novel copper(II) complexes of naphthyl derived 3-hydroxy-4-pyridinone chelators. Their antibacterial activity against several Gram-positive and Gram-negative reference strains and multidrug-resistant clinical isolates was assessed through determination of the minimum inhibitory concentration (MIC). The complex Cu(naph1pp) 2 shows the highest antibacterial activity, including against multidrug-resistant isolates, nonetheless, being more active against Gram-positive than Gram-negative bacteria. Cu(naph1pp) 2 was further explored in combinatorial tests with ciprofloxacin against methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus faecalis (VRE). The combination of Cu(naph1pp) 2 and ciprofloxacin is considered additive, i.e., the effect of the two compounds combined is stronger than that of the individual compounds in the equivalent concentration.",

keywords = "3-hydroxy-4-pyridinones, Antibacterial activity, Copper(II) complexes, Multidrug-resistant isolates, Synergy with ciprofloxacin",

author = "Andreia Leite and Bessa, \{Lucinda J.\} and Silva, \{Ana M.G.\} and Paula Gameiro and \{de Castro\}, Baltazar and Maria Rangel",

note = "Publisher Copyright: {\textcopyright} 2019 Elsevier Inc.",

year = "2019",

month = aug,

doi = "10.1016/j.jinorgbio.2019.110704",

language = "English",

volume = "197",

journal = "Journal of Inorganic Biochemistry",

issn = "0162-0134",

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TY - JOUR

T1 - Antibacterial activity of naphthyl derived bis-(3-hydroxy-4-pyridinonate) copper(II) complexes against multidrug-resistant bacteria

AU - Leite, Andreia

AU - Bessa, Lucinda J.

AU - Silva, Ana M.G.

AU - Gameiro, Paula

AU - de Castro, Baltazar

AU - Rangel, Maria

PY - 2019/8

Y1 - 2019/8

N2 - In this work, we report the synthesis and characterization of three novel copper(II) complexes of naphthyl derived 3-hydroxy-4-pyridinone chelators. Their antibacterial activity against several Gram-positive and Gram-negative reference strains and multidrug-resistant clinical isolates was assessed through determination of the minimum inhibitory concentration (MIC). The complex Cu(naph1pp) 2 shows the highest antibacterial activity, including against multidrug-resistant isolates, nonetheless, being more active against Gram-positive than Gram-negative bacteria. Cu(naph1pp) 2 was further explored in combinatorial tests with ciprofloxacin against methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus faecalis (VRE). The combination of Cu(naph1pp) 2 and ciprofloxacin is considered additive, i.e., the effect of the two compounds combined is stronger than that of the individual compounds in the equivalent concentration.

AB - In this work, we report the synthesis and characterization of three novel copper(II) complexes of naphthyl derived 3-hydroxy-4-pyridinone chelators. Their antibacterial activity against several Gram-positive and Gram-negative reference strains and multidrug-resistant clinical isolates was assessed through determination of the minimum inhibitory concentration (MIC). The complex Cu(naph1pp) 2 shows the highest antibacterial activity, including against multidrug-resistant isolates, nonetheless, being more active against Gram-positive than Gram-negative bacteria. Cu(naph1pp) 2 was further explored in combinatorial tests with ciprofloxacin against methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus faecalis (VRE). The combination of Cu(naph1pp) 2 and ciprofloxacin is considered additive, i.e., the effect of the two compounds combined is stronger than that of the individual compounds in the equivalent concentration.

KW - 3-hydroxy-4-pyridinones

KW - Antibacterial activity

KW - Copper(II) complexes

KW - Multidrug-resistant isolates

KW - Synergy with ciprofloxacin

UR - https://www.scopus.com/pages/publications/85065442743

U2 - 10.1016/j.jinorgbio.2019.110704

DO - 10.1016/j.jinorgbio.2019.110704

M3 - Article

C2 - 31078872

AN - SCOPUS:85065442743

SN - 0162-0134

VL - 197

JO - Journal of Inorganic Biochemistry

JF - Journal of Inorganic Biochemistry

M1 - 110704

ER -

Antibacterial activity of naphthyl derived bis-(3-hydroxy-4-pyridinonate) copper(II) complexes against multidrug-resistant bacteria

Abstract

UN SDGs

Keywords

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