Antiretroviral drug resistance surveillance among treatment-naive human immunodeficiency virus type 1-infected individuals in Angola: Evidence for low level of transmitted drug resistance

Inês Bártolo; Cheila Rocha; José Bartolomeu; António Gama; Marlene Fonseca; Ana Mendes; Filipa Cristina; Sven Thamm; Marta Epalanga; Patrícia Cavaco Silva; Nuno Taveira

doi:10.1128/AAC.00110-09

Antiretroviral drug resistance surveillance among treatment-naive human immunodeficiency virus type 1-infected individuals in Angola: Evidence for low level of transmitted drug resistance

Inês Bártolo, Cheila Rocha, José Bartolomeu, António Gama, Marlene Fonseca, Ana Mendes, Filipa Cristina, Sven Thamm, Marta Epalanga, Patrícia Cavaco Silva, Nuno Taveira

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19 Citations (Scopus)

Abstract

The prevalence of transmitted human immunodeficiency virus type 1 drug resistance in Angola in 2001 in 196 untreated patients was investigated. All subtypes were detected, along with unclassifiable and complex recombinant strains. Numerous new polymorphisms were identified in the reverse transcriptase and protease. Two (1.6%) unrelated patients harbored nucleoside reverse transcriptase inhibitor- and nonnucleoside reverse transcriptase inhibitor-resistant viruses (mutations: M41L, D67N, M184V, L210W, T215Y or T215F, and K103N). Continued surveillance of drug resistance is required for maximization of ART efficacy in Angola.

Original language	English
Pages (from-to)	3156-3158
Number of pages	3
Journal	Antimicrobial Agents and Chemotherapy
Volume	53
Issue number	7
DOIs	https://doi.org/10.1128/AAC.00110-09
Publication status	Published - Jul 2009

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Bártolo, I., Rocha, C., Bartolomeu, J., Gama, A., Fonseca, M., Mendes, A., Cristina, F., Thamm, S., Epalanga, M., Silva, P. C., & Taveira, N. (2009). Antiretroviral drug resistance surveillance among treatment-naive human immunodeficiency virus type 1-infected individuals in Angola: Evidence for low level of transmitted drug resistance. Antimicrobial Agents and Chemotherapy, 53(7), 3156-3158. https://doi.org/10.1128/AAC.00110-09

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abstract = "The prevalence of transmitted human immunodeficiency virus type 1 drug resistance in Angola in 2001 in 196 untreated patients was investigated. All subtypes were detected, along with unclassifiable and complex recombinant strains. Numerous new polymorphisms were identified in the reverse transcriptase and protease. Two (1.6%) unrelated patients harbored nucleoside reverse transcriptase inhibitor- and nonnucleoside reverse transcriptase inhibitor-resistant viruses (mutations: M41L, D67N, M184V, L210W, T215Y or T215F, and K103N). Continued surveillance of drug resistance is required for maximization of ART efficacy in Angola.",

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Bártolo, I, Rocha, C, Bartolomeu, J, Gama, A, Fonseca, M, Mendes, A, Cristina, F, Thamm, S, Epalanga, M, Silva, PC & Taveira, N 2009, 'Antiretroviral drug resistance surveillance among treatment-naive human immunodeficiency virus type 1-infected individuals in Angola: Evidence for low level of transmitted drug resistance', Antimicrobial Agents and Chemotherapy, vol. 53, no. 7, pp. 3156-3158. https://doi.org/10.1128/AAC.00110-09

Antiretroviral drug resistance surveillance among treatment-naive human immunodeficiency virus type 1-infected individuals in Angola: Evidence for low level of transmitted drug resistance. / Bártolo, Inês; Rocha, Cheila; Bartolomeu, José et al.
In: Antimicrobial Agents and Chemotherapy, Vol. 53, No. 7, 07.2009, p. 3156-3158.

Research output: Contribution to journal › Article › peer-review

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T1 - Antiretroviral drug resistance surveillance among treatment-naive human immunodeficiency virus type 1-infected individuals in Angola

T2 - Evidence for low level of transmitted drug resistance

AU - Bártolo, Inês

AU - Rocha, Cheila

AU - Bartolomeu, José

AU - Gama, António

AU - Fonseca, Marlene

AU - Mendes, Ana

AU - Cristina, Filipa

AU - Thamm, Sven

AU - Epalanga, Marta

AU - Silva, Patrícia Cavaco

AU - Taveira, Nuno

PY - 2009/7

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Antiretroviral drug resistance surveillance among treatment-naive human immunodeficiency virus type 1-infected individuals in Angola: Evidence for low level of transmitted drug resistance

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