Chemical characterization of a red raspberry fruit extract and evaluation of its pharmacological effects in experimental models of acute inflammation and collagen-induced arthritis

M. E. Figueira; M. B. Câmara; R. Direito; J. Rocha; A. T. Serra; C. M.M. Duarte; A. Fernandes; M. Freitas; E. Fernandes; M. C. Marques; M. R. Bronze; B. Sepodes

doi:10.1039/c4fo00376d

Chemical characterization of a red raspberry fruit extract and evaluation of its pharmacological effects in experimental models of acute inflammation and collagen-induced arthritis

M. E. Figueira, M. B. Câmara, R. Direito, J. Rocha, A. T. Serra, C. M.M. Duarte, A. Fernandes, M. Freitas, E. Fernandes, M. C. Marques, M. R. Bronze, B. Sepodes

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Abstract

Berries are an important dietary source of fibres, vitamins, minerals and some biologically active non-nutrients. A red raspberry fruit extract was characterized in terms of phenolic content and the anti-inflammatory properties and protective effects were evaluated in two experimental models of inflammation. The antioxidant potential of the extract, the cellular antioxidant activity and the effects over neutrophils' oxidative burst were also studied to provide a mechanistic insight for the anti-inflammatory effects observed. The extract was administered in a dose of 15 mg kg^-1, i.p. and significantly inhibited paw oedema formation in the rat. The same dose was administered via i.p. and p.o. routes in the collagen-induced arthritis model in the rat. The extract showed pharmacological activity and was able to significantly reduce the development of clinical signs of arthritis and markedly reduce the degree of bone resorption, soft tissue swelling and osteophyte formation, preventing articular destruction in treated animals.

Original language	English
Pages (from-to)	3241-3251
Number of pages	11
Journal	Food and Function
Volume	5
Issue number	12
DOIs	https://doi.org/10.1039/c4fo00376d
Publication status	Published - 1 Dec 2014
Externally published	Yes

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Figueira, M. E., Câmara, M. B., Direito, R., Rocha, J., Serra, A. T., Duarte, C. M. M., Fernandes, A., Freitas, M., Fernandes, E., Marques, M. C., Bronze, M. R., & Sepodes, B. (2014). Chemical characterization of a red raspberry fruit extract and evaluation of its pharmacological effects in experimental models of acute inflammation and collagen-induced arthritis. Food and Function, 5(12), 3241-3251. https://doi.org/10.1039/c4fo00376d

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title = "Chemical characterization of a red raspberry fruit extract and evaluation of its pharmacological effects in experimental models of acute inflammation and collagen-induced arthritis",

abstract = "Berries are an important dietary source of fibres, vitamins, minerals and some biologically active non-nutrients. A red raspberry fruit extract was characterized in terms of phenolic content and the anti-inflammatory properties and protective effects were evaluated in two experimental models of inflammation. The antioxidant potential of the extract, the cellular antioxidant activity and the effects over neutrophils' oxidative burst were also studied to provide a mechanistic insight for the anti-inflammatory effects observed. The extract was administered in a dose of 15 mg kg-1, i.p. and significantly inhibited paw oedema formation in the rat. The same dose was administered via i.p. and p.o. routes in the collagen-induced arthritis model in the rat. The extract showed pharmacological activity and was able to significantly reduce the development of clinical signs of arthritis and markedly reduce the degree of bone resorption, soft tissue swelling and osteophyte formation, preventing articular destruction in treated animals.",

author = "Figueira, {M. E.} and C{\^a}mara, {M. B.} and R. Direito and J. Rocha and Serra, {A. T.} and Duarte, {C. M.M.} and A. Fernandes and M. Freitas and E. Fernandes and Marques, {M. C.} and Bronze, {M. R.} and B. Sepodes",

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Figueira, ME, Câmara, MB, Direito, R, Rocha, J, Serra, AT, Duarte, CMM, Fernandes, A, Freitas, M, Fernandes, E, Marques, MC, Bronze, MR & Sepodes, B 2014, 'Chemical characterization of a red raspberry fruit extract and evaluation of its pharmacological effects in experimental models of acute inflammation and collagen-induced arthritis', Food and Function, vol. 5, no. 12, pp. 3241-3251. https://doi.org/10.1039/c4fo00376d

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AU - Figueira, M. E.

AU - Câmara, M. B.

AU - Direito, R.

AU - Rocha, J.

AU - Serra, A. T.

AU - Duarte, C. M.M.

AU - Fernandes, A.

AU - Freitas, M.

AU - Fernandes, E.

AU - Marques, M. C.

AU - Bronze, M. R.

AU - Sepodes, B.

PY - 2014/12/1

Y1 - 2014/12/1

N2 - Berries are an important dietary source of fibres, vitamins, minerals and some biologically active non-nutrients. A red raspberry fruit extract was characterized in terms of phenolic content and the anti-inflammatory properties and protective effects were evaluated in two experimental models of inflammation. The antioxidant potential of the extract, the cellular antioxidant activity and the effects over neutrophils' oxidative burst were also studied to provide a mechanistic insight for the anti-inflammatory effects observed. The extract was administered in a dose of 15 mg kg-1, i.p. and significantly inhibited paw oedema formation in the rat. The same dose was administered via i.p. and p.o. routes in the collagen-induced arthritis model in the rat. The extract showed pharmacological activity and was able to significantly reduce the development of clinical signs of arthritis and markedly reduce the degree of bone resorption, soft tissue swelling and osteophyte formation, preventing articular destruction in treated animals.

AB - Berries are an important dietary source of fibres, vitamins, minerals and some biologically active non-nutrients. A red raspberry fruit extract was characterized in terms of phenolic content and the anti-inflammatory properties and protective effects were evaluated in two experimental models of inflammation. The antioxidant potential of the extract, the cellular antioxidant activity and the effects over neutrophils' oxidative burst were also studied to provide a mechanistic insight for the anti-inflammatory effects observed. The extract was administered in a dose of 15 mg kg-1, i.p. and significantly inhibited paw oedema formation in the rat. The same dose was administered via i.p. and p.o. routes in the collagen-induced arthritis model in the rat. The extract showed pharmacological activity and was able to significantly reduce the development of clinical signs of arthritis and markedly reduce the degree of bone resorption, soft tissue swelling and osteophyte formation, preventing articular destruction in treated animals.

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Chemical characterization of a red raspberry fruit extract and evaluation of its pharmacological effects in experimental models of acute inflammation and collagen-induced arthritis

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