Clean synthesis of molecular recognition polymeric materials with chiral sensing capability using supercritical fluid technology. Application as HPLC stationary phases

Mara Soares da Silva, Eva R. Vão, Márcio Temtem, Luís Mafra, Jorge Caldeira, Ana Aguiar-Ricardo, Teresa Casimiro

Research output: Contribution to journalArticlepeer-review

66 Citations (Scopus)

Abstract

Molecularly imprinted polymers (MIPs) of poly(ethylene glycol dimethacrylate) and poly(Nisopropylacrylamide- co-ethylene glycol dimethacrylate) were synthesized for the first time in supercritical carbon dioxide (scCO2), using Boc-l-tryptophan as template. Supercritical fluid technology provides a clean and one-step synthetic route for the preparation of affinity polymeric materials with sensing capability for specific molecules. The polymeric materials were tested as stationary HPLC phases for the enantiomeric separation of l- and d-tryptophan. HPLC results prove that the synthesized MIPs are able to recognize the template molecule towards its enantiomer which opens up potential applications in chromatographic chiral separation.

Original languageEnglish
Pages (from-to)1742-1747
Number of pages6
JournalBiosensors and Bioelectronics
Volume25
Issue number7
DOIs
Publication statusPublished - 15 Mar 2010

Keywords

  • Enantiomeric separation
  • HPLC
  • MIP
  • Molecular imprinting
  • Supercritical fluid technology
  • Tryptophan

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