Abstract
Molecularly imprinted polymers (MIPs) of poly(ethylene glycol dimethacrylate) and poly(Nisopropylacrylamide- co-ethylene glycol dimethacrylate) were synthesized for the first time in supercritical carbon dioxide (scCO2), using Boc-l-tryptophan as template. Supercritical fluid technology provides a clean and one-step synthetic route for the preparation of affinity polymeric materials with sensing capability for specific molecules. The polymeric materials were tested as stationary HPLC phases for the enantiomeric separation of l- and d-tryptophan. HPLC results prove that the synthesized MIPs are able to recognize the template molecule towards its enantiomer which opens up potential applications in chromatographic chiral separation.
Original language | English |
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Pages (from-to) | 1742-1747 |
Number of pages | 6 |
Journal | Biosensors and Bioelectronics |
Volume | 25 |
Issue number | 7 |
DOIs | |
Publication status | Published - 15 Mar 2010 |
Keywords
- Enantiomeric separation
- HPLC
- MIP
- Molecular imprinting
- Supercritical fluid technology
- Tryptophan