“Clicking” an Ionic Liquid to a Potent Antimicrobial Peptide: On the Route Towards Improved Stability

Ana Gomes; Lucinda J. Bessa; Patrícia Correia; Iva Fernandes; Ricardo Ferraz; Paula Gameiro; Cátia Teixeira; Paula Gomes

doi:10.3390/ijms21176174

“Clicking” an Ionic Liquid to a Potent Antimicrobial Peptide: On the Route Towards Improved Stability

Ana Gomes, Lucinda J. Bessa, Patrícia Correia, Iva Fernandes, Ricardo Ferraz, Paula Gameiro, Cátia Teixeira, Paula Gomes

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

A covalent conjugate between an antibacterial ionic liquid and an antimicrobial peptide was produced via “click” chemistry, and found to retain the parent peptide’s activity against multidrug-resistant clinical isolates of Gram-negative bacteria, and antibiofilm action on a resistant clinical isolate of Klebsiella pneumoniae, while exhibiting much improved stability towards tyrosinase-mediated modifications. This unprecedented communication is a prelude for the promise held by ionic liquids-based approaches as tools to improve the action of bioactive peptides.

Original language	English
Article number	6174
Pages (from-to)	1-11
Number of pages	11
Journal	International Journal of Molecular Sciences
Volume	21
Issue number	17
DOIs	https://doi.org/10.3390/ijms21176174
Publication status	Published - 1 Sept 2020
Externally published	Yes

Keywords

Antibacterial
Antibiofilm
Ionic liquid
Multidrug resistance
Peptide
Skin infections
Tyrosinase
Wound healing

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/ijms21176174

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title = "“Clicking” an Ionic Liquid to a Potent Antimicrobial Peptide: On the Route Towards Improved Stability",

abstract = "A covalent conjugate between an antibacterial ionic liquid and an antimicrobial peptide was produced via “click” chemistry, and found to retain the parent peptide{\textquoteright}s activity against multidrug-resistant clinical isolates of Gram-negative bacteria, and antibiofilm action on a resistant clinical isolate of Klebsiella pneumoniae, while exhibiting much improved stability towards tyrosinase-mediated modifications. This unprecedented communication is a prelude for the promise held by ionic liquids-based approaches as tools to improve the action of bioactive peptides.",

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T2 - On the Route Towards Improved Stability

AU - Gomes, Ana

AU - Bessa, Lucinda J.

AU - Correia, Patrícia

AU - Fernandes, Iva

AU - Ferraz, Ricardo

AU - Gameiro, Paula

AU - Teixeira, Cátia

AU - Gomes, Paula

PY - 2020/9/1

Y1 - 2020/9/1

N2 - A covalent conjugate between an antibacterial ionic liquid and an antimicrobial peptide was produced via “click” chemistry, and found to retain the parent peptide’s activity against multidrug-resistant clinical isolates of Gram-negative bacteria, and antibiofilm action on a resistant clinical isolate of Klebsiella pneumoniae, while exhibiting much improved stability towards tyrosinase-mediated modifications. This unprecedented communication is a prelude for the promise held by ionic liquids-based approaches as tools to improve the action of bioactive peptides.

AB - A covalent conjugate between an antibacterial ionic liquid and an antimicrobial peptide was produced via “click” chemistry, and found to retain the parent peptide’s activity against multidrug-resistant clinical isolates of Gram-negative bacteria, and antibiofilm action on a resistant clinical isolate of Klebsiella pneumoniae, while exhibiting much improved stability towards tyrosinase-mediated modifications. This unprecedented communication is a prelude for the promise held by ionic liquids-based approaches as tools to improve the action of bioactive peptides.

KW - Antibacterial

KW - Antibiofilm

KW - Ionic liquid

KW - Multidrug resistance

KW - Peptide

KW - Skin infections

KW - Tyrosinase

KW - Wound healing

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ER -

“Clicking” an Ionic Liquid to a Potent Antimicrobial Peptide: On the Route Towards Improved Stability

Abstract

Keywords

UN SDGs

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