Comparative Efficacy of Neuromodulation and Structured Exercise Program on Autonomic Modulation in Fibromyalgia Patients: Pilot Study

Alejandro Rubio-Zarapuz, María Dolores Apolo-Arenas, Orlando Fernandes, José Francisco Tornero-Aguilera, Vicente J. Clemente-Suárez, Jose A. Parraca

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Fibromyalgia is a chronic disorder marked by widespread muscle and joint pain, persistent fatigue, sleep disturbances, and irregularities in the autonomic nervous system (ANS). Methods: This study compared the effectiveness of neuromodulation using the EXOPULSE Mollii suit with a structured exercise program in regulating ANS function in fibromyalgia patients. In this randomized, longitudinal crossover study, 10 female patients were randomly assigned to either the Suit + Exercise group or the Exercise + Suit group. Each group participated in two sessions per week for eight weeks, followed by a two-week washout period before switching to the other intervention. We measured cortical arousal, microcirculation, and heart rate variability (HRV) before and after the 1st, 8th, and 16th sessions. Results: The results showed significant improvements in cortical arousal, HRV, and microcirculation with the neuromodulation treatment whereas the exercise program only produced short-term improvements in cortical arousal. Conclusion: The EXOPULSE Mollii suit exhibited cumulative benefits on ANS modulation over time, suggesting potential long-term advantages for managing fibromyalgia. However, further research is needed to explore the delayed effects of both treatments on ANS modulation.

Original languageEnglish
Article number4288
JournalJournal of Clinical Medicine
Volume13
Issue number15
DOIs
Publication statusPublished - Aug 2024
Externally publishedYes

Keywords

  • autonomic modulation
  • cortical arousal
  • exercise
  • fibromyalgia
  • heart rate variability
  • neuromodulation therapy

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