TY - JOUR
T1 - Comparison of the effects of treatment of peri-implant infection in animal and human studies
T2 - Systematic review and meta-analysis
AU - Faggion, Clovis Mariano
AU - Chambrone, Leandro
AU - Gondim, Valéria
AU - Schmitter, Marc
AU - Tu, Yu Kang
PY - 2010/2
Y1 - 2010/2
N2 - Objective: The main objective of this systematic review is to compare the effects of treatment of peri-implant infection between animal and human studies. Material and methods: A literature search was conducted using the Medline, Cochrane Central Register of Controlled Trials, and Latin American and Caribbean Health Sciences Literature databases up to and including May 2008. In addition, bibliographies of systematic reviews on peri-implant diseases were searched manually. Non-surgical and surgical treatments of peri-implantitis/mucositis in animal models or human studies were compared. Meta-analysis was conducted to investigate the difference between the reported treatment effects in animal and human studies. Changes in probing pocket depth (PPD) and probing attachment level (PAL) from baseline measurements were used as measures of outcome. Single-level and multilevel meta-regression analysis was performed by taking into account the different follow-up times of the studies included. Results: The single-level and multilevel random-effects meta-analysis showed that the difference in PPD reduction [0.31 mm, 95% confidence interval (CI): -0.27, 0.88] and in PAL gain (0.21 mm, 95% CI: -0.47, 0.88) between animal and human studies was not statistically significant. The random-effects meta-regression suggested that studies with longer follow-up times revealed greater PPD reduction (0.25 mm per month, 95% CI: 0.14, 0.35). However, when the different follow-up times were taken into account, these differences became greater. Substantial heterogeneity between studies was found in the meta-analyses (I 2=97.6% for animal studies and 99.9% for human studies). Conclusion: There was great heterogeneity between human and animal studies in terms of study designs and treatment procedures. Therefore, the results from this meta-analysis should be interpreted with caution. Heterogeneity between studies and its causes merit further investigations.
AB - Objective: The main objective of this systematic review is to compare the effects of treatment of peri-implant infection between animal and human studies. Material and methods: A literature search was conducted using the Medline, Cochrane Central Register of Controlled Trials, and Latin American and Caribbean Health Sciences Literature databases up to and including May 2008. In addition, bibliographies of systematic reviews on peri-implant diseases were searched manually. Non-surgical and surgical treatments of peri-implantitis/mucositis in animal models or human studies were compared. Meta-analysis was conducted to investigate the difference between the reported treatment effects in animal and human studies. Changes in probing pocket depth (PPD) and probing attachment level (PAL) from baseline measurements were used as measures of outcome. Single-level and multilevel meta-regression analysis was performed by taking into account the different follow-up times of the studies included. Results: The single-level and multilevel random-effects meta-analysis showed that the difference in PPD reduction [0.31 mm, 95% confidence interval (CI): -0.27, 0.88] and in PAL gain (0.21 mm, 95% CI: -0.47, 0.88) between animal and human studies was not statistically significant. The random-effects meta-regression suggested that studies with longer follow-up times revealed greater PPD reduction (0.25 mm per month, 95% CI: 0.14, 0.35). However, when the different follow-up times were taken into account, these differences became greater. Substantial heterogeneity between studies was found in the meta-analyses (I 2=97.6% for animal studies and 99.9% for human studies). Conclusion: There was great heterogeneity between human and animal studies in terms of study designs and treatment procedures. Therefore, the results from this meta-analysis should be interpreted with caution. Heterogeneity between studies and its causes merit further investigations.
KW - Animal studies
KW - Meta-analysis
KW - Peri-implantitis
KW - Systematic review
UR - http://www.scopus.com/inward/record.url?scp=74249086704&partnerID=8YFLogxK
U2 - 10.1111/j.1600-0501.2009.01753.x
DO - 10.1111/j.1600-0501.2009.01753.x
M3 - Article
C2 - 19912272
AN - SCOPUS:74249086704
SN - 0905-7161
VL - 21
SP - 137
EP - 147
JO - Clinical Oral Implants Research
JF - Clinical Oral Implants Research
IS - 2
ER -