TY - JOUR
T1 - Cork-based activated carbons as supported adsorbent materials for trace level analysis of ibuprofen and clofibric acid in environmental and biological matrices
AU - Neng, N. R.
AU - Mestre, A. S.
AU - Carvalho, A. P.
AU - Nogueira, J. M.F.
N1 - Funding Information:
This work was supported by FCT (Portugal) through the pluriannual programme of CQB. Nuno R. Neng and Ana S. Mestre thank FCT for the PhD grants ( SFRH/BD/38660/2007 and SFRH/BD/17942/2004 , respectively). The authors thank Generis Farmacêutica S.A. (Portugal) for the ibuprofen supply, SimTejo (Portugal) for the wastewater samples and Dr. J. Pires for his helpful technical assistance.
PY - 2011/9/16
Y1 - 2011/9/16
N2 - In this contribution, powdered activated carbons (ACs) from cork waste were supported for bar adsorptive micro-extraction (BAμE), as novel adsorbent phases for the analysis of polar compounds. By combining this approach with liquid desorption followed by high performance liquid chromatography with diode array detection (BAμE(AC)-LD/HPLC-DAD), good analytical performance was achieved using clofibric acid (CLOF) and ibuprofen (IBU) model compounds in environmental and biological matrices. Assays performed on 30mL water samples spiked at the 25.0μgL-1 level yielded recoveries around 80% for CLOF and 95% for IBU, under optimized experimental conditions. The ACs textural and surface chemistry properties were correlated with the results obtained. The analytical performance showed good precision (<15%), suitable detection limits (0.24 and 0.78μgL-1 for CLOF and IBU, respectively) and good linear dynamic ranges (r2>0.9922) from 1.0 to 600.0μgL-1. By using the standard addition methodology, the application of the present approach to environmental water and urine matrices allowed remarkable performance at the trace level. The proposed methodology proved to be a viable alternative for acidic pharmaceuticals analysis, showing to be easy to implement, reliable, sensitive and requiring low sample volume to monitor these priority compounds in environmental and biological matrices.
AB - In this contribution, powdered activated carbons (ACs) from cork waste were supported for bar adsorptive micro-extraction (BAμE), as novel adsorbent phases for the analysis of polar compounds. By combining this approach with liquid desorption followed by high performance liquid chromatography with diode array detection (BAμE(AC)-LD/HPLC-DAD), good analytical performance was achieved using clofibric acid (CLOF) and ibuprofen (IBU) model compounds in environmental and biological matrices. Assays performed on 30mL water samples spiked at the 25.0μgL-1 level yielded recoveries around 80% for CLOF and 95% for IBU, under optimized experimental conditions. The ACs textural and surface chemistry properties were correlated with the results obtained. The analytical performance showed good precision (<15%), suitable detection limits (0.24 and 0.78μgL-1 for CLOF and IBU, respectively) and good linear dynamic ranges (r2>0.9922) from 1.0 to 600.0μgL-1. By using the standard addition methodology, the application of the present approach to environmental water and urine matrices allowed remarkable performance at the trace level. The proposed methodology proved to be a viable alternative for acidic pharmaceuticals analysis, showing to be easy to implement, reliable, sensitive and requiring low sample volume to monitor these priority compounds in environmental and biological matrices.
KW - Bar adsorptive micro-extraction (BAμE)
KW - Biological matrices
KW - Clofibric acid
KW - Cork-based activated carbons
KW - Environmental matrices
KW - HPLC-DAD
KW - Ibuprofen
UR - http://www.scopus.com/inward/record.url?scp=80051862328&partnerID=8YFLogxK
U2 - 10.1016/j.chroma.2011.07.025
DO - 10.1016/j.chroma.2011.07.025
M3 - Article
C2 - 21820664
AN - SCOPUS:80051862328
SN - 0021-9673
VL - 1218
SP - 6263
EP - 6270
JO - Journal of Chromatography A
JF - Journal of Chromatography A
IS - 37
ER -