Delivery of therapeutic proteins for wound healing

This chapter provides an in-depth analysis of the role of therapeutic proteins in wound healing, and the challenges and advances in their delivery. Nonhealing wounds represent a significant healthcare concern worldwide are exacerbated by increasing diabetes and obesity rates. Therapeutic proteins, including growth factors, cytokines, and enzymes, are crucial in wound healing, facilitating various stages from hemostasis to tissue regeneration. However, their effective delivery is hindered by the protease-rich, hostile wound environment and physiological barriers like the skin. Innovative delivery systems, including controlled release systems, nanoparticle-based delivery, and biodegradable scaffolds have been developed to address these challenges. They offer sustained release, protection from degradation, and targeted delivery, enhancing therapeutic outcomes. The chapter delves into various nanoparticle types and compositions, their role in controlled release, and their advantages in different wound contexts. Preclinical studies and clinical trials are discussed to evaluate the safety and efficacy of these delivery systems. Examples include chitosan nanoparticles for insulin delivery in diabetic wounds and temperature-responsive hydrogels for vascularization. The chapter concludes by emphasizing the potential of therapeutic proteins in wound care, despite challenges in stability, cost, and accessibility, highlighting the need for multidisciplinary collaboration for innovative solutions in wound healing.