TY - JOUR
T1 - Dental tissue-derived stem cell sheet biotechnology for periodontal tissue regeneration
T2 - A systematic review
AU - Magalhães, Fabiana Divina
AU - Sarra, Giovanna
AU - Carvalho, Giovanna Lopes
AU - Pedroni, Ana Clara Fagundes
AU - Marques, Márcia Martins
AU - Chambrone, Leandro
AU - Gimenez, Thaís
AU - Moreira, Maria Stella
N1 - Publisher Copyright:
© 2021 Elsevier Ltd
PY - 2021/9
Y1 - 2021/9
N2 - Objective: This study aimed to conduct a systematic review of the use of a cell sheet formed by mesenchymal stem cells derived from dental tissues (ddMSCs) for periodontal tissue regeneration in animal models in comparison with any other type of regenerative treatment. Design: PubMed and Scopus databases were searched for relevant studies up to December 2020. The review was conducted based on the Preferred Reporting Items for Systematic Reviews and Meta-analysis guidelines. Results: Of the 1542 potentially relevant articles initially identified, 33 fulfilled the eligibility criteria and were considered for this review. Even with a wide variety of selected study methods, the periodontal tissue was always regenerated; this indicates the potential for the use of these cell sheets in the future of periodontics. However, this regeneration process is not always complete. Conclusion: Despite the implantation, ddMSCs sheets have a great potential to be used in the regeneration of periodontal tissue. More in vivo studies should be conducted using standardized techniques for cell sheet implantation to obtain more robust evidence of the relevance of using this modality of cell therapy for periodontal tissue regeneration.
AB - Objective: This study aimed to conduct a systematic review of the use of a cell sheet formed by mesenchymal stem cells derived from dental tissues (ddMSCs) for periodontal tissue regeneration in animal models in comparison with any other type of regenerative treatment. Design: PubMed and Scopus databases were searched for relevant studies up to December 2020. The review was conducted based on the Preferred Reporting Items for Systematic Reviews and Meta-analysis guidelines. Results: Of the 1542 potentially relevant articles initially identified, 33 fulfilled the eligibility criteria and were considered for this review. Even with a wide variety of selected study methods, the periodontal tissue was always regenerated; this indicates the potential for the use of these cell sheets in the future of periodontics. However, this regeneration process is not always complete. Conclusion: Despite the implantation, ddMSCs sheets have a great potential to be used in the regeneration of periodontal tissue. More in vivo studies should be conducted using standardized techniques for cell sheet implantation to obtain more robust evidence of the relevance of using this modality of cell therapy for periodontal tissue regeneration.
KW - Cell sheet
KW - Dental tissue-derived
KW - Periodontal tissue
KW - Stem cells
KW - Tissue engineering
KW - Tissue regeneration
UR - http://www.scopus.com/inward/record.url?scp=85108241171&partnerID=8YFLogxK
U2 - 10.1016/j.archoralbio.2021.105182
DO - 10.1016/j.archoralbio.2021.105182
M3 - Review article
C2 - 34098416
AN - SCOPUS:85108241171
SN - 0003-9969
VL - 129
JO - Archives of Oral Biology
JF - Archives of Oral Biology
M1 - 105182
ER -