Differentiation of isomeric arylamine adducts of deoxyguanosine by electrospray ionization and quadrupole ion trap mass spectrometry

Linge Li; M. Paul Chiarelli; Paula S. Branco; Alexandra M. Antunes; Matilde M. Marques; Luisa L. Gonçalves; Frederick A. Beland

Differentiation of isomeric arylamine adducts of deoxyguanosine by electrospray ionization and quadrupole ion trap mass spectrometry

Linge Li, M. Paul Chiarelli, Paula S. Branco, Alexandra M. Antunes, Matilde M. Marques, Luisa L. Gonçalves, Frederick A. Beland

Research output: Contribution to conference › Paper › peer-review

Abstract

The structural differentiation of isomeric C8-substituted alklaniline adducts of guanine electrospray ionization and quadrupole ion trap mass spectrometry were discussed. The BH ₂ ⁺ ions formed by these adducts were subjected to CAD to determine the differentiation. Isomer differentiation was accomplished by the observation of the structure-specific fragmentation pathways or the the calculation of similarity index (SI). It was observed that the SI's computed for the comparison of different tandem mass spectra acquired from the same isomer range from 8 ± 2 to 12 ± 4.

Original language	English
Pages	395-396
Number of pages	2
Publication status	Published - 2002
Externally published	Yes
Event	Proceedings - 50th ASMS Conference on Mass Spectrometry and Allied Topics - Orlando, FL, United States Duration: 2 Jun 2002 → 6 Jun 2002

Conference

Conference	Proceedings - 50th ASMS Conference on Mass Spectrometry and Allied Topics
Country/Territory	United States
City	Orlando, FL
Period	2/06/02 → 6/06/02

Cite this

Li, L., Chiarelli, M. P., Branco, P. S., Antunes, A. M., Marques, M. M., Gonçalves, L. L., & Beland, F. A. (2002). Differentiation of isomeric arylamine adducts of deoxyguanosine by electrospray ionization and quadrupole ion trap mass spectrometry. 395-396. Paper presented at Proceedings - 50th ASMS Conference on Mass Spectrometry and Allied Topics, Orlando, FL, United States.

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title = "Differentiation of isomeric arylamine adducts of deoxyguanosine by electrospray ionization and quadrupole ion trap mass spectrometry",

abstract = "The structural differentiation of isomeric C8-substituted alklaniline adducts of guanine electrospray ionization and quadrupole ion trap mass spectrometry were discussed. The BH 2 + ions formed by these adducts were subjected to CAD to determine the differentiation. Isomer differentiation was accomplished by the observation of the structure-specific fragmentation pathways or the the calculation of similarity index (SI). It was observed that the SI's computed for the comparison of different tandem mass spectra acquired from the same isomer range from 8 ± 2 to 12 ± 4.",

author = "Linge Li and Chiarelli, {M. Paul} and Branco, {Paula S.} and Antunes, {Alexandra M.} and Marques, {Matilde M.} and Gon{\c c}alves, {Luisa L.} and Beland, {Frederick A.}",

year = "2002",

language = "English",

pages = "395--396",

note = "Proceedings - 50th ASMS Conference on Mass Spectrometry and Allied Topics ; Conference date: 02-06-2002 Through 06-06-2002",

}

Li, L, Chiarelli, MP, Branco, PS, Antunes, AM, Marques, MM, Gonçalves, LL & Beland, FA 2002, 'Differentiation of isomeric arylamine adducts of deoxyguanosine by electrospray ionization and quadrupole ion trap mass spectrometry', Paper presented at Proceedings - 50th ASMS Conference on Mass Spectrometry and Allied Topics, Orlando, FL, United States, 2/06/02 - 6/06/02 pp. 395-396.

Differentiation of isomeric arylamine adducts of deoxyguanosine by electrospray ionization and quadrupole ion trap mass spectrometry. / Li, Linge; Chiarelli, M. Paul; Branco, Paula S. et al.
2002. 395-396 Paper presented at Proceedings - 50th ASMS Conference on Mass Spectrometry and Allied Topics, Orlando, FL, United States.

Research output: Contribution to conference › Paper › peer-review

TY - CONF

T1 - Differentiation of isomeric arylamine adducts of deoxyguanosine by electrospray ionization and quadrupole ion trap mass spectrometry

AU - Li, Linge

AU - Chiarelli, M. Paul

AU - Branco, Paula S.

AU - Antunes, Alexandra M.

AU - Marques, Matilde M.

AU - Gonçalves, Luisa L.

AU - Beland, Frederick A.

PY - 2002

Y1 - 2002

N2 - The structural differentiation of isomeric C8-substituted alklaniline adducts of guanine electrospray ionization and quadrupole ion trap mass spectrometry were discussed. The BH 2 + ions formed by these adducts were subjected to CAD to determine the differentiation. Isomer differentiation was accomplished by the observation of the structure-specific fragmentation pathways or the the calculation of similarity index (SI). It was observed that the SI's computed for the comparison of different tandem mass spectra acquired from the same isomer range from 8 ± 2 to 12 ± 4.

AB - The structural differentiation of isomeric C8-substituted alklaniline adducts of guanine electrospray ionization and quadrupole ion trap mass spectrometry were discussed. The BH 2 + ions formed by these adducts were subjected to CAD to determine the differentiation. Isomer differentiation was accomplished by the observation of the structure-specific fragmentation pathways or the the calculation of similarity index (SI). It was observed that the SI's computed for the comparison of different tandem mass spectra acquired from the same isomer range from 8 ± 2 to 12 ± 4.

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M3 - Paper

AN - SCOPUS:2442674408

SP - 395

EP - 396

T2 - Proceedings - 50th ASMS Conference on Mass Spectrometry and Allied Topics

Y2 - 2 June 2002 through 6 June 2002

ER -

Differentiation of isomeric arylamine adducts of deoxyguanosine by electrospray ionization and quadrupole ion trap mass spectrometry

Abstract

Conference

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