Does cannula's size alter rheological properties of hyaluronic acid filler?

Andrea Lisboa Sisnando, Vasudev Vivekanand Nayak, Mariana Barbosa Câmara-Sousa, Omar Neves Morphy, Gisele R.D. Furtado, Lukasz Witek, Ana Claudia Carbone, Célia Marisa Rizzatti-Barbosa, Giancarlo De la Torre Canales

Research output: Contribution to journalArticlepeer-review

Abstract

This study evaluated the rheological properties of various hyaluronic acid (HA) gels after passing through different-sized cannulas (22-G and 25-G). Five commercial brands of highly crosslinked HA fillers were analyzed: (A) Rennova® Ultra Deep, (B) Restylane® Lyft, (C) Hialurox® - Ultra Lift, (D) Belotero® Volume, and (E) E.P.T.Q S500. Rheological characterization was conducted using an automated controlled stress rheometer. The rheological properties of the fillers were assessed both before and after passing through the cannulas. Each filler brand and cannula size was tested three times by a researcher who was blinded to the commercial brands. For data analysis, frequencies of 0.1, 0.5, and 2 Hz were employed. The rheological properties (storage modulus [G'] and loss modulus [G"]) of the high-crosslink HA fillers did not change after being passed through cannulas of different sizes (22-G and 25-G) (p > 0.109) compared to baseline measurements (no cannula). Furthermore, all fillers displayed desirable solid-like, volumizing behavior at low frequencies and strain amplitudes (<10 %). Under physiologically relevant conditions for skin and facial applications, the cannula size did not alter the rheological properties of high crosslink HA fillers.

Original languageEnglish
Article number135915
JournalInternational Journal of Biological Macromolecules
Volume281
DOIs
Publication statusPublished - Nov 2024

Keywords

  • Cannula
  • Fillers
  • Hyaluronic acid
  • Polymers
  • Rheological properties

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