TY - JOUR
T1 - Drilling into “Quality by Design” Approach for Analytical Methods
AU - Chiarentin, Lucas
AU - Gonçalves, Carla
AU - Augusto, Cátia
AU - Miranda, Margarida
AU - Cardoso, Catarina
AU - Vitorino, Carla
N1 - Publisher Copyright:
© 2023 Taylor & Francis Group, LLC.
PY - 2023/8
Y1 - 2023/8
N2 - The need for consistency in analytical method development reinforces the dependence of pharmaceutical product development and manufacturing on robust analytical data. The Analytical Quality by Design (AQbD), akin to the product Quality by Design (QbD) endows a high degree of confidence to the method quality developed. AQbD involves the definition of the analytical target profile as starting point, followed by the identification of critical method variables and critical analytical attributes, supported on risk assessment and design of experiment tools for the establishment of a method operable design region and control strategy of the method. This systematic approach moves away from reactive troubleshooting to proactive failure reduction. The objective of this review is to highlight the elements of the AQbD framework and provide an overview of their implementation status in various analytical methods used in the pharmaceutical field. These methodologies include but are not limited to, high-performance liquid chromatography, UV-Vis spectrophotometry, capillary electrophoresis, supercritical fluid chromatography, and high-performance thin-layer chromatography. Finally, a critical appraisal is provided to highlight how regulators have encouraged AQbD principles application to boost the prevention of method failures and a better understanding of the method operable design region (MODR) and control strategy, ultimately resulting in cost-effectiveness and regulatory flexibility.
AB - The need for consistency in analytical method development reinforces the dependence of pharmaceutical product development and manufacturing on robust analytical data. The Analytical Quality by Design (AQbD), akin to the product Quality by Design (QbD) endows a high degree of confidence to the method quality developed. AQbD involves the definition of the analytical target profile as starting point, followed by the identification of critical method variables and critical analytical attributes, supported on risk assessment and design of experiment tools for the establishment of a method operable design region and control strategy of the method. This systematic approach moves away from reactive troubleshooting to proactive failure reduction. The objective of this review is to highlight the elements of the AQbD framework and provide an overview of their implementation status in various analytical methods used in the pharmaceutical field. These methodologies include but are not limited to, high-performance liquid chromatography, UV-Vis spectrophotometry, capillary electrophoresis, supercritical fluid chromatography, and high-performance thin-layer chromatography. Finally, a critical appraisal is provided to highlight how regulators have encouraged AQbD principles application to boost the prevention of method failures and a better understanding of the method operable design region (MODR) and control strategy, ultimately resulting in cost-effectiveness and regulatory flexibility.
KW - Analytical methods
KW - analytical methodologies
KW - analytical quality by design (AQbD)
KW - risk assessment
UR - http://www.scopus.com/inward/record.url?scp=85169816043&partnerID=8YFLogxK
U2 - 10.1080/10408347.2023.2253321
DO - 10.1080/10408347.2023.2253321
M3 - Review article
AN - SCOPUS:85169816043
SN - 1040-8347
JO - Critical Reviews in Analytical Chemistry
JF - Critical Reviews in Analytical Chemistry
ER -