TY - JOUR
T1 - Effect of Genetic Polymorphisms on Pain Sensitivity in the Orofacial Region
T2 - A Systematic Review
AU - Soares, Flavia Fonseca Carvalho
AU - Poluha, Rodrigo Lorenzi
AU - Canales, Giancarlo De la Torre
AU - Costa, Yuri Martins
AU - Nascimento, Gustavo G.
AU - Conti, Paulo César Rodrigues
AU - Bonjardim, Leonardo Rigoldi
N1 - Publisher Copyright:
© 2020 by Quintessence Publishing Conc.
PY - 2020
Y1 - 2020
N2 - To systematically review the literature to assess whether genetic polymorphisms affect orofacial pain sensitivity in healthy individuals and in patients with chronic orofacial pain disorders. Methods: Electronic searches were conducted to identify observational studies and clinical trials investigating the association between genetic polymorphisms and orofacial pain sensitivity in healthy individuals and/or patients with chronic orofacial pain disorders. Searches were carried out in PubMed, Embase, and Scopus databases using Medical Subject Headings and free terms. Results: Seven studies fulfilled the eligibility criteria: four analyzed healthy subjects, two included chronic orofacial pain patients, and one included samples of healthy subjects and patients with neuropathic pain. The results showed that genes associated with mechanical and thermal pain sensitivity were mostly related to opioid, catecholaminergic, inflammatory, and dopaminergic pathways. Conclusion: Genetic polymorphisms related to opioid, catecholaminergic, inflammatory, and dopaminergic pathways were associated with sensitivity to thermal and pressure stimuli in the orofacial region. Therefore, genetic factors should be taken into account for an accurate interpretation of orofacial pain sensitivity. These results will allow for a better understanding of the etiopathogenesis of chronic pain affecting the orofacial region, and consequently for finding new therapeutic targets. J Oral Facial Pain Headache 2020;34:353-363. dof: 10.11607/ofph.2641
AB - To systematically review the literature to assess whether genetic polymorphisms affect orofacial pain sensitivity in healthy individuals and in patients with chronic orofacial pain disorders. Methods: Electronic searches were conducted to identify observational studies and clinical trials investigating the association between genetic polymorphisms and orofacial pain sensitivity in healthy individuals and/or patients with chronic orofacial pain disorders. Searches were carried out in PubMed, Embase, and Scopus databases using Medical Subject Headings and free terms. Results: Seven studies fulfilled the eligibility criteria: four analyzed healthy subjects, two included chronic orofacial pain patients, and one included samples of healthy subjects and patients with neuropathic pain. The results showed that genes associated with mechanical and thermal pain sensitivity were mostly related to opioid, catecholaminergic, inflammatory, and dopaminergic pathways. Conclusion: Genetic polymorphisms related to opioid, catecholaminergic, inflammatory, and dopaminergic pathways were associated with sensitivity to thermal and pressure stimuli in the orofacial region. Therefore, genetic factors should be taken into account for an accurate interpretation of orofacial pain sensitivity. These results will allow for a better understanding of the etiopathogenesis of chronic pain affecting the orofacial region, and consequently for finding new therapeutic targets. J Oral Facial Pain Headache 2020;34:353-363. dof: 10.11607/ofph.2641
KW - chronic pain
KW - genetic polymorphism
KW - orofacial region
KW - pain sensitivity
KW - quantitative sensory testing
UR - http://www.scopus.com/inward/record.url?scp=85097514452&partnerID=8YFLogxK
M3 - Article
C2 - 33290441
AN - SCOPUS:85097514452
SN - 2333-0384
VL - 34
SP - 353
EP - 363
JO - Journal of Oral and Facial Pain and Headache
JF - Journal of Oral and Facial Pain and Headache
IS - 6
ER -