Effective management of multidrug-resistant HIV with lenacapavir and fostemsavir: A case study

Francisca Bartilotti Matos; Dara Mbanze; Perpétua Gomes; Cristóvão Figueiredo; Daniel Coutinho; Sofia Nunes; Carlos Azevedo; Joana Fragoso; Tiago Teixeira; Luís Malheiro

doi:10.1177/09564624241296583

Effective management of multidrug-resistant HIV with lenacapavir and fostemsavir: A case study

Francisca Bartilotti Matos, Dara Mbanze, Perpétua Gomes, Cristóvão Figueiredo, Daniel Coutinho, Sofia Nunes, Carlos Azevedo, Joana Fragoso, Tiago Teixeira, Luís Malheiro

Research output: Contribution to journal › Article › peer-review

Abstract

Resistance to antiretroviral therapy is an increasing challenge in the management of HIV. We present the case of a woman living with HIV, with a history of multiple treatment regimens and resistances to antiretrovirals, who has been successfully treated with a combination of lenacapavir and fostemsavir for the past year, obtaining an undetectable viral load within one month of starting therapy and reporting no serious side effects. This case is amongst the first to document the combined use of lenacapivir and fostemsavir in treating multidrug-resistant HIV. It supports the potential of these novel agents in managing complex cases of HIV resistance.

Original language	English
Journal	International Journal of STD and AIDS
DOIs	https://doi.org/10.1177/09564624241296583
Publication status	Accepted/In press - 2024

Keywords

antiviral
ART (antiretroviral therapy)
HIV (Human immunodeficiency virus)
other
treatment
viral disease

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1177/09564624241296583

Cite this

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abstract = "Resistance to antiretroviral therapy is an increasing challenge in the management of HIV. We present the case of a woman living with HIV, with a history of multiple treatment regimens and resistances to antiretrovirals, who has been successfully treated with a combination of lenacapavir and fostemsavir for the past year, obtaining an undetectable viral load within one month of starting therapy and reporting no serious side effects. This case is amongst the first to document the combined use of lenacapivir and fostemsavir in treating multidrug-resistant HIV. It supports the potential of these novel agents in managing complex cases of HIV resistance.",

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doi = "10.1177/09564624241296583",

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T1 - Effective management of multidrug-resistant HIV with lenacapavir and fostemsavir

T2 - A case study

AU - Matos, Francisca Bartilotti

AU - Mbanze, Dara

AU - Gomes, Perpétua

AU - Figueiredo, Cristóvão

AU - Coutinho, Daniel

AU - Nunes, Sofia

AU - Azevedo, Carlos

AU - Fragoso, Joana

AU - Teixeira, Tiago

AU - Malheiro, Luís

PY - 2024

Y1 - 2024

N2 - Resistance to antiretroviral therapy is an increasing challenge in the management of HIV. We present the case of a woman living with HIV, with a history of multiple treatment regimens and resistances to antiretrovirals, who has been successfully treated with a combination of lenacapavir and fostemsavir for the past year, obtaining an undetectable viral load within one month of starting therapy and reporting no serious side effects. This case is amongst the first to document the combined use of lenacapivir and fostemsavir in treating multidrug-resistant HIV. It supports the potential of these novel agents in managing complex cases of HIV resistance.

AB - Resistance to antiretroviral therapy is an increasing challenge in the management of HIV. We present the case of a woman living with HIV, with a history of multiple treatment regimens and resistances to antiretrovirals, who has been successfully treated with a combination of lenacapavir and fostemsavir for the past year, obtaining an undetectable viral load within one month of starting therapy and reporting no serious side effects. This case is amongst the first to document the combined use of lenacapivir and fostemsavir in treating multidrug-resistant HIV. It supports the potential of these novel agents in managing complex cases of HIV resistance.

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KW - ART (antiretroviral therapy)

KW - HIV (Human immunodeficiency virus)

KW - other

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JO - International Journal of STD and AIDS

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Effective management of multidrug-resistant HIV with lenacapavir and fostemsavir: A case study

Abstract

Keywords

UN SDGs

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