Effective management of multidrug-resistant HIV with lenacapavir and fostemsavir: A case study

Francisca Bartilotti Matos, Dara Mbanze, Perpétua Gomes, Cristóvão Figueiredo, Daniel Coutinho, Sofia Nunes, Carlos Azevedo, Joana Fragoso, Tiago Teixeira, Luís Malheiro

Research output: Contribution to journalArticlepeer-review

Abstract

Resistance to antiretroviral therapy is an increasing challenge in the management of HIV. We present the case of a woman living with HIV, with a history of multiple treatment regimens and resistances to antiretrovirals, who has been successfully treated with a combination of lenacapavir and fostemsavir for the past year, obtaining an undetectable viral load within one month of starting therapy and reporting no serious side effects. This case is amongst the first to document the combined use of lenacapivir and fostemsavir in treating multidrug-resistant HIV. It supports the potential of these novel agents in managing complex cases of HIV resistance.

Original languageEnglish
JournalInternational Journal of STD and AIDS
DOIs
Publication statusAccepted/In press - 2024

Keywords

  • antiviral
  • ART (antiretroviral therapy)
  • HIV (Human immunodeficiency virus)
  • other
  • treatment
  • viral disease

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