TY - JOUR
T1 - Effectiveness, Adherence and Safety of Home High Flow Nasal Cannula in Chronic Respiratory Disease and Respiratory Insufficiency
T2 - A Systematic Review
AU - Jácome, Cristina
AU - Jácome, Marta
AU - Correia, Sara
AU - Flores, Inês
AU - Farinha, Patrícia
AU - Duarte, Mónica
AU - Winck, João Carlos
AU - Sayas Catalan, Javier
AU - Díaz Lobato, Salvador
AU - Luján, Manel
AU - Caneiras, Cátia
N1 - Publisher Copyright:
© 2024 The Authors
PY - 2024/8
Y1 - 2024/8
N2 - Introduction: The effectiveness of home high flow nasal cannula (HFNC) for the treatment of chronic respiratory failure in patients with chronic respiratory diseases (CRDs) has not been summarized. We aimed to conduct a systematic review of the effectiveness, adherence, and safety of HFNC in the long-term treatment of patients with chronic respiratory diseases and respiratory failure. Methods: A systematic review was conducted. PubMed, Web of science, and SCOPUS were search up to August 2023. Long-term HFNC studies (≥4 weeks) reporting dyspnea; exacerbations, hospitalizations; peripheral oxygen saturation (SpO2), comfort; patient experience, health-related quality of life or partial pressure of carbon dioxide (paCO2) were included. Results: Thirteen articles (701 patients) based on 10 studies were selected: randomized control trials (n = 3), randomized crossover trials (n = 2), crossover (n = 3) and retrospective (n = 2) studies. COPD (n = 6), bronchiectasis (n = 2), COPD/bronchiectasis (n = 1) and ILD (n = 1) were the underlined CRDs. HFNC reduced exacerbations when compared to usual care/home respiratory therapies (n = 6). Quality of life outcomes were also in favor of HFNC in patients with COPD and bronchiectasis (n = 6). HFNC had significant effects on hospitalizations, paCO2, and lung function. Adherence ranged from 5.2 to 8.6 h/day (n = 5). Three studies reported no events, 3 non-serious events and 2 no differences compared with other home respiratory therapies. Conclusions: HFNC seems more effective than usual care or other home respiratory therapies in reducing exacerbations and improving quality of life in patients with COPD and bronchiectasis, while presenting good adherence and being safe. Its apparently superior effectiveness needs to be better studied in future real-world pragmatic trials.
AB - Introduction: The effectiveness of home high flow nasal cannula (HFNC) for the treatment of chronic respiratory failure in patients with chronic respiratory diseases (CRDs) has not been summarized. We aimed to conduct a systematic review of the effectiveness, adherence, and safety of HFNC in the long-term treatment of patients with chronic respiratory diseases and respiratory failure. Methods: A systematic review was conducted. PubMed, Web of science, and SCOPUS were search up to August 2023. Long-term HFNC studies (≥4 weeks) reporting dyspnea; exacerbations, hospitalizations; peripheral oxygen saturation (SpO2), comfort; patient experience, health-related quality of life or partial pressure of carbon dioxide (paCO2) were included. Results: Thirteen articles (701 patients) based on 10 studies were selected: randomized control trials (n = 3), randomized crossover trials (n = 2), crossover (n = 3) and retrospective (n = 2) studies. COPD (n = 6), bronchiectasis (n = 2), COPD/bronchiectasis (n = 1) and ILD (n = 1) were the underlined CRDs. HFNC reduced exacerbations when compared to usual care/home respiratory therapies (n = 6). Quality of life outcomes were also in favor of HFNC in patients with COPD and bronchiectasis (n = 6). HFNC had significant effects on hospitalizations, paCO2, and lung function. Adherence ranged from 5.2 to 8.6 h/day (n = 5). Three studies reported no events, 3 non-serious events and 2 no differences compared with other home respiratory therapies. Conclusions: HFNC seems more effective than usual care or other home respiratory therapies in reducing exacerbations and improving quality of life in patients with COPD and bronchiectasis, while presenting good adherence and being safe. Its apparently superior effectiveness needs to be better studied in future real-world pragmatic trials.
KW - Chronic obstructive pulmonary disease
KW - High-flow cannula
KW - High-flow nasal cannula oxygen therapy
KW - Hypercapnic
KW - Nasal high-flow
KW - Pulmonary disease
UR - http://www.scopus.com/inward/record.url?scp=85193928805&partnerID=8YFLogxK
U2 - 10.1016/j.arbres.2024.05.001
DO - 10.1016/j.arbres.2024.05.001
M3 - Review article
AN - SCOPUS:85193928805
SN - 0300-2896
VL - 60
SP - 490
EP - 502
JO - Archivos de Bronconeumologia
JF - Archivos de Bronconeumologia
IS - 8
ER -
