Emerging patterns in HIV integrase resistance

Margarida Veloso; Marta Ribeiro; Joaquim Cabanas; Fátima Gonçalves; Sandra Fernandes; Isabel Diogo; Inês Costa; Victor Pimentel; Marta Pingarilho; Ana Abecasis; Perpétua Gomes

doi:10.1097/QAD.0000000000004322

Emerging patterns in HIV integrase resistance

Margarida Veloso
, Marta Ribeiro
, Joaquim Cabanas
, Fátima Gonçalves
, Sandra Fernandes
, Isabel Diogo
, Inês Costa
, Victor Pimentel
, Marta Pingarilho
, Ana Abecasis
, Perpétua Gomes

Research output: Contribution to journal › Article › peer-review

Abstract

We assessed integrase resistance in 837 treatment-experienced people with HIV (PWH) with virological failure (2022–2024) in Portugal. Major resistance mutations were found in 5.5%, with N155H and R263K being the most common. Resistance was more frequent in non-B subtypes and often co-occurred with resistance to other antiretroviral classes. Though prevalence remains low, the findings highlight the need for continued surveillance to inform treatment decisions, especially as integrase inhibitors like dolutegravir, bictegravir and cabotegravir become more widely used.

Original language	English
Pages (from-to)	2324-2327
Number of pages	4
Journal	AIDS
Volume	39
Issue number	15
DOIs	https://doi.org/10.1097/QAD.0000000000004322
Publication status	Published - Nov 2025

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10.1097/QAD.0000000000004322

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title = "Emerging patterns in HIV integrase resistance",

abstract = "We assessed integrase resistance in 837 treatment-experienced people with HIV (PWH) with virological failure (2022–2024) in Portugal. Major resistance mutations were found in 5.5\%, with N155H and R263K being the most common. Resistance was more frequent in non-B subtypes and often co-occurred with resistance to other antiretroviral classes. Though prevalence remains low, the findings highlight the need for continued surveillance to inform treatment decisions, especially as integrase inhibitors like dolutegravir, bictegravir and cabotegravir become more widely used.",

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T1 - Emerging patterns in HIV integrase resistance

AU - Veloso, Margarida

AU - Ribeiro, Marta

AU - Cabanas, Joaquim

AU - Gonçalves, Fátima

AU - Fernandes, Sandra

AU - Diogo, Isabel

AU - Costa, Inês

AU - Pimentel, Victor

AU - Pingarilho, Marta

AU - Abecasis, Ana

AU - Gomes, Perpétua

PY - 2025/11

Y1 - 2025/11

N2 - We assessed integrase resistance in 837 treatment-experienced people with HIV (PWH) with virological failure (2022–2024) in Portugal. Major resistance mutations were found in 5.5%, with N155H and R263K being the most common. Resistance was more frequent in non-B subtypes and often co-occurred with resistance to other antiretroviral classes. Though prevalence remains low, the findings highlight the need for continued surveillance to inform treatment decisions, especially as integrase inhibitors like dolutegravir, bictegravir and cabotegravir become more widely used.

AB - We assessed integrase resistance in 837 treatment-experienced people with HIV (PWH) with virological failure (2022–2024) in Portugal. Major resistance mutations were found in 5.5%, with N155H and R263K being the most common. Resistance was more frequent in non-B subtypes and often co-occurred with resistance to other antiretroviral classes. Though prevalence remains low, the findings highlight the need for continued surveillance to inform treatment decisions, especially as integrase inhibitors like dolutegravir, bictegravir and cabotegravir become more widely used.

UR - https://www.scopus.com/pages/publications/105021798473

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DO - 10.1097/QAD.0000000000004322

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SN - 0269-9370

VL - 39

SP - 2324

EP - 2327

JO - AIDS

JF - AIDS

IS - 15

ER -

Emerging patterns in HIV integrase resistance

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