TY - JOUR
T1 - Expression of chikungunya virus-like particles
AU - Velez, R. A.
AU - De Matos, A. P.Alves
AU - Parreira, R.
AU - Matos, J. Piedade B.
AU - Correia, C.
AU - Esteves, A.
PY - 2012/10
Y1 - 2012/10
N2 - Chikungunya virus (CHIKV) is a mosquito-transmitted alphavirus responsible for painful disabling polyarthritis, undergoing re-emergence in the Indian Ocean and the Asian continent. Travelling and changing patterns of vector distribution, and abundance due to climate changes, make CHIKV a global threat without effective control strategies. One approach to reduce the CHIKV burden is the development of a vaccine. Virus-like particles (VLPs) are a safe and highly effective class of subunit vaccines that mimic the overall structure of virus particles. Accordingly, we aim to produce CHIKV VLPs in a baculovirus-insect cell system, well known for allowing high yields of recombinant protein expression, to be used as a vaccine preparation.
AB - Chikungunya virus (CHIKV) is a mosquito-transmitted alphavirus responsible for painful disabling polyarthritis, undergoing re-emergence in the Indian Ocean and the Asian continent. Travelling and changing patterns of vector distribution, and abundance due to climate changes, make CHIKV a global threat without effective control strategies. One approach to reduce the CHIKV burden is the development of a vaccine. Virus-like particles (VLPs) are a safe and highly effective class of subunit vaccines that mimic the overall structure of virus particles. Accordingly, we aim to produce CHIKV VLPs in a baculovirus-insect cell system, well known for allowing high yields of recombinant protein expression, to be used as a vaccine preparation.
UR - http://www.scopus.com/inward/record.url?scp=84892813497&partnerID=8YFLogxK
U2 - 10.1017/S1431927612012950
DO - 10.1017/S1431927612012950
M3 - Article
AN - SCOPUS:84892813497
SN - 1431-9276
VL - 18
SP - 59
EP - 60
JO - Microscopy and Microanalysis
JF - Microscopy and Microanalysis
IS - SUPPL.5
ER -