Abstract
This work reports for the first time the in vitro anti Leishmania infantum activity of acetone and dichloromethane (DCM) extracts from 25 extremophile plants from Southern Portugal. DCM extracts from Inula chritmoides and Spergularia rubra were active against axenic promastigotes and intracellular amastigotes, had anti-inflammatory properties on lipopolysaccharide (LPS)-stimulated macrophages, inhibited acetylcholinesterase and had no haemolytic activity on human erythrocytes. Eleven phenolics were identified by high-performance liquid chromatography with diode-array detection (HPLC-DAD) in I. crithmoides and one phenolic in S. rubra. Isolation and identification of the active molecules is in progress.
Original language | English |
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Pages (from-to) | 600-604 |
Number of pages | 5 |
Journal | Natural Product Research |
Volume | 32 |
Issue number | 5 |
DOIs | |
Publication status | Published - 4 Mar 2018 |
Externally published | Yes |
Keywords
- Antiparasitic
- Inula chritmoides
- Leishmania infantum
- Spergularia rubra
- halophytes
- neglected tropical diseases
- visceral leishmaniasis