Flow Chemistry: Towards A More Sustainable Heterocyclic Synthesis

Flow Chemistry is a revolutionary field in Organic Chemistry. By changing the conventional methods and apparatus applied in the chemical synthesis, flow chemistry emerges as a game changer for organic synthesis laboratories, in both academia and industries. Considered as a sustainable practice, flow processes play an important role in the development of fine chemical products and in drug discovery development programs. This work aims to review the recent contributions on heterocyclic synthesis under continuous-flow conditions, focusing in heterocycle ring formation and highlighting some of the most recent examples found in the literature, as well as some synthetic strategies aiming for the flow preparation of high-value chemical products, such as APIs and agrochemicals.