Helicobacter pylori phage screening

Filipa F. Vale, António P.A. Matos, Patrícia Carvalho, Jorge M.B. Vtor

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)

Abstract

Helicobacter pylori is a helical shaped Gram-negative bacterium that colonizes the human stomach. It is associated with several human pathologies, such as gastritis, peptic ulcer, and gastric cancer. The standard first-line treatment is a one week triple therapy: the association of two antibiotics, most frequently amoxicillin and clarithromycin, and a proton pump inhibior. Despite the evolution of the treatment strategy, quadruple therapy, there is an increasing percentage of failure of the antibiotic therapy, due to antibiotics resistance. Phage therapy is the therapeutic use of lytic bacteriophages to treat pathogenic bacterial infections and H. pylori is a good target. However there are no available phage collections, and H. pylori phages description is diminutive on literature.

Original languageEnglish
Pages (from-to)150-151
Number of pages2
JournalMicroscopy and Microanalysis
Volume14
Issue numberSUPPL. 3
DOIs
Publication statusPublished - Sept 2008
Externally publishedYes

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