Abstract
1. Close arterial infusion of clenbuterol (0.7 μg/hr) for a 3 hr period led to decreased protein synthesis and degradation (both P < 0.05) across the hind-limb of sheep. 2. Systemic infusion of the drug (14 μg/hr) for a similar period increased blood flow (P < 0.001) through the hind-limb and decreased protein degradation (P < 0.05). 3. Following chronic (7 day) close-arterial infusion of clenbuterol (1.9 μg/hr) hind-limb protein synthesis and degradation again declined (P < 0.05) but this was apparently not recovered during 7 days of drug withdrawal. 4. In consequence, during subsequent systemic infusion of the drug (62 μg/hr) the lower rates of protein metabolism were not altered significantly, despite improved whole nitrogen retention (+ 30%, P < 0.01). 5. The results are discussed with reference to the differential actions of β-agonists on the various tissues of the hind-limb.
| Original language | English |
|---|---|
| Pages (from-to) | 529-535 |
| Number of pages | 7 |
| Journal | Comparative biochemistry and physiology. C: Comparative pharmacology |
| Volume | 106 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Oct 1993 |
| Externally published | Yes |