TY - JOUR
T1 - HIV-1-Transmitted Drug Resistance and Transmission Clusters in Newly Diagnosed Patients in Portugal Between 2014 and 2019
AU - the BESTHOPE Study Group
AU - Pingarilho, Marta
AU - Pimentel, Victor
AU - Miranda, Mafalda N.S.
AU - Silva, Ana Rita
AU - Diniz, António
AU - Ascenção, Bianca Branco
AU - Piñeiro, Carmela
AU - Koch, Carmo
AU - Rodrigues, Catarina
AU - Caldas, Cátia
AU - Morais, Célia
AU - Faria, Domitília
AU - da Silva, Elisabete Gomes
AU - Teófilo, Eugénio
AU - Monteiro, Fátima
AU - Roxo, Fausto
AU - Maltez, Fernando
AU - Rodrigues, Fernando
AU - Gaião, Guilhermina
AU - Ramos, Helena
AU - Costa, Inês
AU - Germano, Isabel
AU - Simões, Joana
AU - Oliveira, Joaquim
AU - Ferreira, José
AU - Poças, José
AU - da Cunha, José Saraiva
AU - Soares, Jorge
AU - Henriques, Júlia
AU - Mansinho, Kamal
AU - Pedro, Liliana
AU - Aleixo, Maria João
AU - Gonçalves, Maria João
AU - Manata, Maria José
AU - Mouro, Margarida
AU - Serrado, Margarida
AU - Caixeiro, Micaela
AU - Marques, Nuno
AU - Costa, Olga
AU - Pacheco, Patrícia
AU - Proença, Paula
AU - Rodrigues, Paulo
AU - Pinho, Raquel
AU - Tavares, Raquel
AU - de Abreu, Ricardo Correia
AU - Côrte-Real, Rita
AU - Serrão, Rosário
AU - Castro, Rui Sarmento e.
AU - Nunes, Sofia
AU - Gomes, Perpétua
N1 - Publisher Copyright:
Copyright © 2022 Pingarilho, Pimentel, Miranda, Silva, Diniz, Ascenção, Piñeiro, Koch, Rodrigues, Caldas, Morais, Faria, da Silva, Teófilo, Monteiro, Roxo, Maltez, Rodrigues, Gaião, Ramos, Costa, Germano, Simões, Oliveira, Ferreira, Poças, da Cunha, Soares, Henriques, Mansinho, Pedro, Aleixo, Gonçalves, Manata, Mouro, Serrado, Caixeiro, Marques, Costa, Pacheco, Proença, Rodrigues, Pinho, Tavares, de Abreu, Côrte-Real, Serrão, Castro, Nunes, Faria, Baptista, Martins, Gomes, Mendão, Simões and Abecasis.
PY - 2022/4/25
Y1 - 2022/4/25
N2 - Objective: To describe and analyze transmitted drug resistance (TDR) between 2014 and 2019 in newly infected patients with HIV-1 in Portugal and to characterize its transmission networks. Methods: Clinical, socioepidemiological, and risk behavior data were collected from 820 newly diagnosed patients in Portugal between September 2014 and December 2019. The sequences obtained from drug resistance testing were used for subtyping, TDR determination, and transmission cluster (TC) analyses. Results: In Portugal, the overall prevalence of TDR between 2014 and 2019 was 11.0%. TDR presented a decreasing trend from 16.7% in 2014 to 9.2% in 2016 (pfor–trend = 0.114). Multivariate analysis indicated that TDR was significantly associated with transmission route (MSM presented a lower probability of presenting TDR when compared to heterosexual contact) and with subtype (subtype C presented significantly more TDR when compared to subtype B). TC analysis corroborated that the heterosexual risk group presented a higher proportion of TDR in TCs when compared to MSMs. Among subtype A1, TDR reached 16.6% in heterosexuals, followed by 14.2% in patients infected with subtype B and 9.4% in patients infected with subtype G. Conclusion: Our molecular epidemiology approach indicates that the HIV-1 epidemic in Portugal is changing among risk group populations, with heterosexuals showing increasing levels of HIV-1 transmission and TDR. Prevention measures for this subpopulation should be reinforced.
AB - Objective: To describe and analyze transmitted drug resistance (TDR) between 2014 and 2019 in newly infected patients with HIV-1 in Portugal and to characterize its transmission networks. Methods: Clinical, socioepidemiological, and risk behavior data were collected from 820 newly diagnosed patients in Portugal between September 2014 and December 2019. The sequences obtained from drug resistance testing were used for subtyping, TDR determination, and transmission cluster (TC) analyses. Results: In Portugal, the overall prevalence of TDR between 2014 and 2019 was 11.0%. TDR presented a decreasing trend from 16.7% in 2014 to 9.2% in 2016 (pfor–trend = 0.114). Multivariate analysis indicated that TDR was significantly associated with transmission route (MSM presented a lower probability of presenting TDR when compared to heterosexual contact) and with subtype (subtype C presented significantly more TDR when compared to subtype B). TC analysis corroborated that the heterosexual risk group presented a higher proportion of TDR in TCs when compared to MSMs. Among subtype A1, TDR reached 16.6% in heterosexuals, followed by 14.2% in patients infected with subtype B and 9.4% in patients infected with subtype G. Conclusion: Our molecular epidemiology approach indicates that the HIV-1 epidemic in Portugal is changing among risk group populations, with heterosexuals showing increasing levels of HIV-1 transmission and TDR. Prevention measures for this subpopulation should be reinforced.
KW - HIV-1
KW - Portugal
KW - TDR
KW - newly infected patients
KW - transmission clusters
UR - http://www.scopus.com/inward/record.url?scp=85131860855&partnerID=8YFLogxK
U2 - 10.3389/fmicb.2022.823208
DO - 10.3389/fmicb.2022.823208
M3 - Article
AN - SCOPUS:85131860855
SN - 1664-302X
VL - 13
JO - Frontiers in Microbiology
JF - Frontiers in Microbiology
M1 - 823208
ER -
