TY - JOUR
T1 - HIV-2 genetic evolution in patients with advanced disease is faster than that in matched HIV-1 patients
AU - Skar, Helena
AU - Borrego, Pedro
AU - Wallstrom, Timothy C.
AU - Mild, Mattias
AU - Marcelino, José Maria
AU - Barroso, Helena
AU - Taveira, Nuno
AU - Leitner, Thomas
AU - Albert, Jan
PY - 2010/7
Y1 - 2010/7
N2 - The objective of this study was to estimate and compare the evolutionary rates of HIV-2 and HIV-1. Two HIV-2 data sets from patients with advanced disease were compared to matched HIV-1 data sets. The estimated mean evolutionary rate of HIV-2 was significantly higher than the estimated rate of HIV-1, both in the gp125 and in the V3 region of the env gene. In addition, the rate of synonymous substitutions in gp125 was significantly higher for HIV-2 than for HIV-1, possibly indicating a shorter generation time or higher mutation rate of HIV-2. Thus, the lower virulence of HIV-2 does not appear to translate into a lower rate of evolution.
AB - The objective of this study was to estimate and compare the evolutionary rates of HIV-2 and HIV-1. Two HIV-2 data sets from patients with advanced disease were compared to matched HIV-1 data sets. The estimated mean evolutionary rate of HIV-2 was significantly higher than the estimated rate of HIV-1, both in the gp125 and in the V3 region of the env gene. In addition, the rate of synonymous substitutions in gp125 was significantly higher for HIV-2 than for HIV-1, possibly indicating a shorter generation time or higher mutation rate of HIV-2. Thus, the lower virulence of HIV-2 does not appear to translate into a lower rate of evolution.
UR - http://www.scopus.com/inward/record.url?scp=77953755556&partnerID=8YFLogxK
U2 - 10.1128/JVI.02548-09
DO - 10.1128/JVI.02548-09
M3 - Article
C2 - 20463072
AN - SCOPUS:77953755556
SN - 0022-538X
VL - 84
SP - 7412
EP - 7415
JO - Journal of Virology
JF - Journal of Virology
IS - 14
ER -
