HIV-2 genetic evolution in patients with advanced disease is faster than that in matched HIV-1 patients

Helena Skar; Pedro Borrego; Timothy C. Wallstrom; Mattias Mild; José Maria Marcelino; Helena Barroso; Nuno Taveira; Thomas Leitner; Jan Albert

doi:10.1128/JVI.02548-09

HIV-2 genetic evolution in patients with advanced disease is faster than that in matched HIV-1 patients

Helena Skar
, Pedro Borrego
, Timothy C. Wallstrom
, Mattias Mild
, José Maria Marcelino
, Helena Barroso
, Nuno Taveira
, Thomas Leitner
, Jan Albert

Research output: Contribution to journal › Article › peer-review

25 Citations (Scopus)

Abstract

The objective of this study was to estimate and compare the evolutionary rates of HIV-2 and HIV-1. Two HIV-2 data sets from patients with advanced disease were compared to matched HIV-1 data sets. The estimated mean evolutionary rate of HIV-2 was significantly higher than the estimated rate of HIV-1, both in the gp125 and in the V3 region of the env gene. In addition, the rate of synonymous substitutions in gp125 was significantly higher for HIV-2 than for HIV-1, possibly indicating a shorter generation time or higher mutation rate of HIV-2. Thus, the lower virulence of HIV-2 does not appear to translate into a lower rate of evolution.

Original language	English
Pages (from-to)	7412-7415
Number of pages	4
Journal	Journal of Virology
Volume	84
Issue number	14
DOIs	https://doi.org/10.1128/JVI.02548-09
Publication status	Published - Jul 2010

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title = "HIV-2 genetic evolution in patients with advanced disease is faster than that in matched HIV-1 patients",

abstract = "The objective of this study was to estimate and compare the evolutionary rates of HIV-2 and HIV-1. Two HIV-2 data sets from patients with advanced disease were compared to matched HIV-1 data sets. The estimated mean evolutionary rate of HIV-2 was significantly higher than the estimated rate of HIV-1, both in the gp125 and in the V3 region of the env gene. In addition, the rate of synonymous substitutions in gp125 was significantly higher for HIV-2 than for HIV-1, possibly indicating a shorter generation time or higher mutation rate of HIV-2. Thus, the lower virulence of HIV-2 does not appear to translate into a lower rate of evolution.",

author = "Helena Skar and Pedro Borrego and Wallstrom, \{Timothy C.\} and Mattias Mild and Marcelino, \{Jos{\'e} Maria\} and Helena Barroso and Nuno Taveira and Thomas Leitner and Jan Albert",

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AU - Skar, Helena

AU - Borrego, Pedro

AU - Wallstrom, Timothy C.

AU - Mild, Mattias

AU - Marcelino, José Maria

AU - Barroso, Helena

AU - Taveira, Nuno

AU - Leitner, Thomas

AU - Albert, Jan

PY - 2010/7

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N2 - The objective of this study was to estimate and compare the evolutionary rates of HIV-2 and HIV-1. Two HIV-2 data sets from patients with advanced disease were compared to matched HIV-1 data sets. The estimated mean evolutionary rate of HIV-2 was significantly higher than the estimated rate of HIV-1, both in the gp125 and in the V3 region of the env gene. In addition, the rate of synonymous substitutions in gp125 was significantly higher for HIV-2 than for HIV-1, possibly indicating a shorter generation time or higher mutation rate of HIV-2. Thus, the lower virulence of HIV-2 does not appear to translate into a lower rate of evolution.

AB - The objective of this study was to estimate and compare the evolutionary rates of HIV-2 and HIV-1. Two HIV-2 data sets from patients with advanced disease were compared to matched HIV-1 data sets. The estimated mean evolutionary rate of HIV-2 was significantly higher than the estimated rate of HIV-1, both in the gp125 and in the V3 region of the env gene. In addition, the rate of synonymous substitutions in gp125 was significantly higher for HIV-2 than for HIV-1, possibly indicating a shorter generation time or higher mutation rate of HIV-2. Thus, the lower virulence of HIV-2 does not appear to translate into a lower rate of evolution.

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ER -

HIV-2 genetic evolution in patients with advanced disease is faster than that in matched HIV-1 patients

Abstract

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