Hospital resource utilization and treatment cost of skeletal-related events in patients with metastatic breast or prostate cancer: Estimation for the Portuguese national health system

J. Félix; V. Andreozzi; M. Soares; P. Borrego; H. Gervásio; A. Moreira; L. Costa; F. Marcelo; F. Peralta; I. Furtado; F. Pina; C. Albuquerque; A. Santos; J. L. Passos-Coelho

doi:10.1016/j.jval.2010.11.014

Hospital resource utilization and treatment cost of skeletal-related events in patients with metastatic breast or prostate cancer: Estimation for the Portuguese national health system

J. Félix, V. Andreozzi, M. Soares, P. Borrego, H. Gervásio, A. Moreira, L. Costa, F. Marcelo, F. Peralta, I. Furtado, F. Pina, C. Albuquerque, A. Santos, J. L. Passos-Coelho

Research output: Contribution to journal › Article › peer-review

32 Citations (Scopus)

Abstract

Background: Skeletal-related events (SREs) occur frequently in patients with bone metastases as a result of breast (BC) and prostate (PC) cancers. They increase both morbidity and mortality and lead to extensive health-care resource utilization. Methods: Health care resource utilization by BC/PC patients with at least one SRE during the preceding 12 months was assessed through retrospective chart review. SRE-treatment costs were estimated using the Portuguese Ministry of Health cost database and analyzed using generalized linear models. Results: This study included 152 patients from nine hospitals. The mean (SD) annual SRE-treatment cost per patient was ε5963 (ε3646) and ε5711 (ε4347), for BC (n=121) and PC (n=31) patients, respectively. Mean cost per single episode ranged between ε1485 (radiotherapy) and ε13,203 (spinal cord compression). Early onset of bone metastasis (P = 0.03) and diagnosis of bone metastases at or after the occurrence of the first SRE (P = 0.001) were associated with higher SRE-treatment costs. Conclusion: These results reveal the high hospital SRE-treatment costs, highlighting the need for early diagnosis and treatment, and identify key factors determining the economic value of therapies for patients with skeletal metastases.

Original language	English
Pages (from-to)	499-505
Number of pages	7
Journal	Value in Health
Volume	14
Issue number	4
DOIs	https://doi.org/10.1016/j.jval.2010.11.014
Publication status	Published - Jun 2011
Externally published	Yes

Keywords

Breast cancer
Costs
Hospital
Prostate cancer
Skeletalrelated events

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.jval.2010.11.014

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Félix, J., Andreozzi, V., Soares, M., Borrego, P., Gervásio, H., Moreira, A., Costa, L., Marcelo, F., Peralta, F., Furtado, I., Pina, F., Albuquerque, C., Santos, A., & Passos-Coelho, J. L. (2011). Hospital resource utilization and treatment cost of skeletal-related events in patients with metastatic breast or prostate cancer: Estimation for the Portuguese national health system. Value in Health, 14(4), 499-505. https://doi.org/10.1016/j.jval.2010.11.014

@article{79e753ad509845188de3158b4dc52370,

title = "Hospital resource utilization and treatment cost of skeletal-related events in patients with metastatic breast or prostate cancer: Estimation for the Portuguese national health system",

abstract = "Background: Skeletal-related events (SREs) occur frequently in patients with bone metastases as a result of breast (BC) and prostate (PC) cancers. They increase both morbidity and mortality and lead to extensive health-care resource utilization. Methods: Health care resource utilization by BC/PC patients with at least one SRE during the preceding 12 months was assessed through retrospective chart review. SRE-treatment costs were estimated using the Portuguese Ministry of Health cost database and analyzed using generalized linear models. Results: This study included 152 patients from nine hospitals. The mean (SD) annual SRE-treatment cost per patient was ε5963 (ε3646) and ε5711 (ε4347), for BC (n=121) and PC (n=31) patients, respectively. Mean cost per single episode ranged between ε1485 (radiotherapy) and ε13,203 (spinal cord compression). Early onset of bone metastasis (P = 0.03) and diagnosis of bone metastases at or after the occurrence of the first SRE (P = 0.001) were associated with higher SRE-treatment costs. Conclusion: These results reveal the high hospital SRE-treatment costs, highlighting the need for early diagnosis and treatment, and identify key factors determining the economic value of therapies for patients with skeletal metastases.",

keywords = "Breast cancer, Costs, Hospital, Prostate cancer, Skeletalrelated events",

author = "J. F{\'e}lix and V. Andreozzi and M. Soares and P. Borrego and H. Gerv{\'a}sio and A. Moreira and L. Costa and F. Marcelo and F. Peralta and I. Furtado and F. Pina and C. Albuquerque and A. Santos and Passos-Coelho, {J. L.}",

note = "Funding Information: Source of financial support: This research was funded by an unrestricted grant from Novartis Oncology Portugal . ",

year = "2011",

month = jun,

doi = "10.1016/j.jval.2010.11.014",

language = "English",

volume = "14",

pages = "499--505",

journal = "Value in Health",

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Félix, J, Andreozzi, V, Soares, M, Borrego, P, Gervásio, H, Moreira, A, Costa, L, Marcelo, F, Peralta, F, Furtado, I, Pina, F, Albuquerque, C, Santos, A & Passos-Coelho, JL 2011, 'Hospital resource utilization and treatment cost of skeletal-related events in patients with metastatic breast or prostate cancer: Estimation for the Portuguese national health system', Value in Health, vol. 14, no. 4, pp. 499-505. https://doi.org/10.1016/j.jval.2010.11.014

TY - JOUR

T1 - Hospital resource utilization and treatment cost of skeletal-related events in patients with metastatic breast or prostate cancer

T2 - Estimation for the Portuguese national health system

AU - Félix, J.

AU - Andreozzi, V.

AU - Soares, M.

AU - Borrego, P.

AU - Gervásio, H.

AU - Moreira, A.

AU - Costa, L.

AU - Marcelo, F.

AU - Peralta, F.

AU - Furtado, I.

AU - Pina, F.

AU - Albuquerque, C.

AU - Santos, A.

AU - Passos-Coelho, J. L.

N1 - Funding Information: Source of financial support: This research was funded by an unrestricted grant from Novartis Oncology Portugal .

PY - 2011/6

Y1 - 2011/6

N2 - Background: Skeletal-related events (SREs) occur frequently in patients with bone metastases as a result of breast (BC) and prostate (PC) cancers. They increase both morbidity and mortality and lead to extensive health-care resource utilization. Methods: Health care resource utilization by BC/PC patients with at least one SRE during the preceding 12 months was assessed through retrospective chart review. SRE-treatment costs were estimated using the Portuguese Ministry of Health cost database and analyzed using generalized linear models. Results: This study included 152 patients from nine hospitals. The mean (SD) annual SRE-treatment cost per patient was ε5963 (ε3646) and ε5711 (ε4347), for BC (n=121) and PC (n=31) patients, respectively. Mean cost per single episode ranged between ε1485 (radiotherapy) and ε13,203 (spinal cord compression). Early onset of bone metastasis (P = 0.03) and diagnosis of bone metastases at or after the occurrence of the first SRE (P = 0.001) were associated with higher SRE-treatment costs. Conclusion: These results reveal the high hospital SRE-treatment costs, highlighting the need for early diagnosis and treatment, and identify key factors determining the economic value of therapies for patients with skeletal metastases.

AB - Background: Skeletal-related events (SREs) occur frequently in patients with bone metastases as a result of breast (BC) and prostate (PC) cancers. They increase both morbidity and mortality and lead to extensive health-care resource utilization. Methods: Health care resource utilization by BC/PC patients with at least one SRE during the preceding 12 months was assessed through retrospective chart review. SRE-treatment costs were estimated using the Portuguese Ministry of Health cost database and analyzed using generalized linear models. Results: This study included 152 patients from nine hospitals. The mean (SD) annual SRE-treatment cost per patient was ε5963 (ε3646) and ε5711 (ε4347), for BC (n=121) and PC (n=31) patients, respectively. Mean cost per single episode ranged between ε1485 (radiotherapy) and ε13,203 (spinal cord compression). Early onset of bone metastasis (P = 0.03) and diagnosis of bone metastases at or after the occurrence of the first SRE (P = 0.001) were associated with higher SRE-treatment costs. Conclusion: These results reveal the high hospital SRE-treatment costs, highlighting the need for early diagnosis and treatment, and identify key factors determining the economic value of therapies for patients with skeletal metastases.

KW - Breast cancer

KW - Costs

KW - Hospital

KW - Prostate cancer

KW - Skeletalrelated events

UR - http://www.scopus.com/inward/record.url?scp=79959995003&partnerID=8YFLogxK

U2 - 10.1016/j.jval.2010.11.014

DO - 10.1016/j.jval.2010.11.014

M3 - Article

AN - SCOPUS:79959995003

SN - 1098-3015

VL - 14

SP - 499

EP - 505

JO - Value in Health

JF - Value in Health

IS - 4

ER -

Hospital resource utilization and treatment cost of skeletal-related events in patients with metastatic breast or prostate cancer: Estimation for the Portuguese national health system

Abstract

Keywords

UN SDGs

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