In the flow of molecular miniaturized fungal diagnosis

Maria Zolotareva, Francisco Cascalheira, Cátia Caneiras, Cristina Bárbara, Diogo Miguel Caetano, Miguel Cacho Teixeira

Research output: Contribution to journalReview articlepeer-review

Abstract

The diagnosis of fungal infections presents several challenges and limitations, stemming from the similarities in symptomatology, diversity of underlying pathogenic species, complexity of fungal biology, and scarcity of rapid, affordable, and point-of-care approaches. In this review, we assess technological advances enabling the conversion of cutting-edge laboratory molecular diagnostic methods to cost-effective microfluidic devices. The most promising strategies toward the design of DNA sequence-based fungal diagnostic systems, capable of capturing and deciphering the highly informative DNA of the pathogen and adapted for resource-limited settings, are discussed, bridging fungal biology, molecular genetics, microfluidics, and biosensors.

Original languageEnglish
Pages (from-to)1628-1643
Number of pages16
JournalTrends in Biotechnology
Volume42
Issue number12
DOIs
Publication statusPublished - Dec 2024

Keywords

  • biosensors
  • fungal infection
  • microfluidics
  • molecular diagnosis

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