In vitro antioxidant and inhibitory activity of water decoctions of carob tree (Ceratonia siliqua L.) on cholinesterases, α-amylase and α-glucosidase

Luísa Custódio, João Patarra, Fernando Alberício, Nuno Rosa Neng, José Manuel Florêncio Nogueira, Anabela Romano

Research output: Contribution to journalArticlepeer-review

46 Citations (Scopus)

Abstract

This work reports the in vitro inhibitory activity of water decoctions of leaves, germ flour, pulp, locust bean gum and stem bark of carob tree on α-amylase, α-glucosidase, acetylcholinesterase and butyrylcholinesterase. The antioxidant activity and the chemical characterisation of the extracts made by spectrophotometric assays and by high-performance liquid chromatography are also reported. Leaves and stem bark decoctions strongly inhibited all the enzymes tested, had significant antioxidant activity and the highest total phenolics content. The major compounds were identified as gallic acid in the leaves and gentisic acid in the stem bark.

Original languageEnglish
Pages (from-to)2155-2159
Number of pages5
JournalNatural Product Research
Volume29
Issue number22
DOIs
Publication statusPublished - 17 Nov 2015
Externally publishedYes

Keywords

  • anti-hyperglycaemic
  • carob tree
  • diabetes
  • neurological disorders

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