Isololiolide, a carotenoid metabolite isolated from the brown alga Cystoseira tamariscifolia, is cytotoxic and able to induce apoptosis in hepatocarcinoma cells through caspase-3 activation, decreased Bcl-2 levels, increased p53 expression and PARP cleavage

Catarina Vizetto-Duarte, Luísa Custódio, Katkam N. Gangadhar, João Henrique G. Lago, Catarina Dias, Ana Marta Matos, Nuno Neng, José Manuel Florêncio Nogueira, Luísa Barreira, Fernando Albericio, Amelia P. Rauter, João Varela

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Immunology and Microbiology

Pharmacology, Toxicology and Pharmaceutical Science