Kinetics of torquetenovirus DNA load in a recent kidney transplant recipient with mild SARS-CoV-2 infection and a failed antibody response

Sara Querido; Rita Calça; André Weigert; Diogo Francisco; Teresa Adragão; Maria Ana Pessanha; Perpétua Gomes; Luís Rodrigues; João M. Figueira; Conceição Cardoso; Domingos Machado

doi:10.1111/tid.13524

Kinetics of torquetenovirus DNA load in a recent kidney transplant recipient with mild SARS-CoV-2 infection and a failed antibody response

Sara Querido, Rita Calça, André Weigert, Diogo Francisco, Teresa Adragão, Maria Ana Pessanha, Perpétua Gomes, Luís Rodrigues, João M. Figueira, Conceição Cardoso, Domingos Machado

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

Kidney transplant (KT) recipients are at an increased risk for severe COVID-19 because of their immunosuppressed state. A 42-year-old KT patient was diagnosed with COVID-19 three months after KT. Despite lymphopenia and several risk factors, he had a mild disease course. Nasopharyngeal real-time reverse transcriptase polymerase chain reaction for SARS-CoV-2 became negative 48 days after detection. SARS‑CoV‑2 IgG antibodies became negative after day 40. TTV DNA load increased with the onset COVID-19 and reduced after its resolution. This is the first report where TTV DNA load was measured during the course of COVID-19.

Original language	English
Article number	e13524
Journal	Transplant Infectious Disease
Volume	23
Issue number	2
DOIs	https://doi.org/10.1111/tid.13524
Publication status	Published - Apr 2021
Externally published	Yes

Keywords

COVID-19
SARS-CoV-2
kidney transplant
torquetenovirus

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/tid.13524

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Querido, S., Calça, R., Weigert, A., Francisco, D., Adragão, T., Ana Pessanha, M., Gomes, P., Rodrigues, L., Figueira, J. M., Cardoso, C., & Machado, D. (2021). Kinetics of torquetenovirus DNA load in a recent kidney transplant recipient with mild SARS-CoV-2 infection and a failed antibody response. Transplant Infectious Disease, 23(2), Article e13524. https://doi.org/10.1111/tid.13524

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title = "Kinetics of torquetenovirus DNA load in a recent kidney transplant recipient with mild SARS-CoV-2 infection and a failed antibody response",

abstract = "Kidney transplant (KT) recipients are at an increased risk for severe COVID-19 because of their immunosuppressed state. A 42-year-old KT patient was diagnosed with COVID-19 three months after KT. Despite lymphopenia and several risk factors, he had a mild disease course. Nasopharyngeal real-time reverse transcriptase polymerase chain reaction for SARS-CoV-2 became negative 48 days after detection. SARS‑CoV‑2 IgG antibodies became negative after day 40. TTV DNA load increased with the onset COVID-19 and reduced after its resolution. This is the first report where TTV DNA load was measured during the course of COVID-19.",

keywords = "COVID-19, SARS-CoV-2, kidney transplant, torquetenovirus",

author = "Sara Querido and Rita Cal{\c c}a and Andr{\'e} Weigert and Diogo Francisco and Teresa Adrag{\~a}o and {Ana Pessanha}, Maria and Perp{\'e}tua Gomes and Lu{\'i}s Rodrigues and Figueira, {Jo{\~a}o M.} and Concei{\c c}{\~a}o Cardoso and Domingos Machado",

note = "Publisher Copyright: {\textcopyright} 2020 Wiley Periodicals LLC",

year = "2021",

month = apr,

doi = "10.1111/tid.13524",

language = "English",

volume = "23",

journal = "Transplant Infectious Disease",

issn = "1398-2273",

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}

Querido, S, Calça, R, Weigert, A, Francisco, D, Adragão, T, Ana Pessanha, M, Gomes, P, Rodrigues, L, Figueira, JM, Cardoso, C & Machado, D 2021, 'Kinetics of torquetenovirus DNA load in a recent kidney transplant recipient with mild SARS-CoV-2 infection and a failed antibody response', Transplant Infectious Disease, vol. 23, no. 2, e13524. https://doi.org/10.1111/tid.13524

TY - JOUR

T1 - Kinetics of torquetenovirus DNA load in a recent kidney transplant recipient with mild SARS-CoV-2 infection and a failed antibody response

AU - Querido, Sara

AU - Calça, Rita

AU - Weigert, André

AU - Francisco, Diogo

AU - Adragão, Teresa

AU - Ana Pessanha, Maria

AU - Gomes, Perpétua

AU - Rodrigues, Luís

AU - Figueira, João M.

AU - Cardoso, Conceição

AU - Machado, Domingos

PY - 2021/4

Y1 - 2021/4

N2 - Kidney transplant (KT) recipients are at an increased risk for severe COVID-19 because of their immunosuppressed state. A 42-year-old KT patient was diagnosed with COVID-19 three months after KT. Despite lymphopenia and several risk factors, he had a mild disease course. Nasopharyngeal real-time reverse transcriptase polymerase chain reaction for SARS-CoV-2 became negative 48 days after detection. SARS‑CoV‑2 IgG antibodies became negative after day 40. TTV DNA load increased with the onset COVID-19 and reduced after its resolution. This is the first report where TTV DNA load was measured during the course of COVID-19.

AB - Kidney transplant (KT) recipients are at an increased risk for severe COVID-19 because of their immunosuppressed state. A 42-year-old KT patient was diagnosed with COVID-19 three months after KT. Despite lymphopenia and several risk factors, he had a mild disease course. Nasopharyngeal real-time reverse transcriptase polymerase chain reaction for SARS-CoV-2 became negative 48 days after detection. SARS‑CoV‑2 IgG antibodies became negative after day 40. TTV DNA load increased with the onset COVID-19 and reduced after its resolution. This is the first report where TTV DNA load was measured during the course of COVID-19.

KW - COVID-19

KW - SARS-CoV-2

KW - kidney transplant

KW - torquetenovirus

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U2 - 10.1111/tid.13524

DO - 10.1111/tid.13524

M3 - Article

C2 - 33226684

AN - SCOPUS:85097103262

SN - 1398-2273

VL - 23

JO - Transplant Infectious Disease

JF - Transplant Infectious Disease

IS - 2

M1 - e13524

ER -

Kinetics of torquetenovirus DNA load in a recent kidney transplant recipient with mild SARS-CoV-2 infection and a failed antibody response

Abstract

Keywords

UN SDGs

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