Lipid composition in liver and brain of genetically obese (ob/ob), heterozygote (ob/+) and normal (+/+) mice

Armando Sena; Gérard Rebel; Robert Bieth; Pierre Hubert; Albert Waksman

doi:10.1016/0005-2760(82)90111-4

Lipid composition in liver and brain of genetically obese (ob/ob), heterozygote (ob/+) and normal (+/+) mice

Armando Sena, Gérard Rebel, Robert Bieth, Pierre Hubert, Albert Waksman

Research output: Contribution to journal › Article › peer-review

21 Citations (Scopus)

Abstract

Lipid composition was studied in liver and brain of normal (+/+), heterozygote (ob/+) and obese (ob/ob) mice. It was found that this genetic defect is expressed differently in the lipid composition of these organs. Cholesterol is increased in liver but strongly decreased in brain of obese animals. Phosphatide fatty acid composition is modified in liver and not in brain. In contrast, phospholipids and total ganglioside sialic acid are affected similarly in both organs. Although clinically normal, heterozygote (ob/+) mice already show an abnormal lipid composition in liver and brain. The potential importance of these results is presented.

Original language	English
Pages (from-to)	290-296
Number of pages	7
Journal	Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids
Volume	710
Issue number	3
DOIs	https://doi.org/10.1016/0005-2760(82)90111-4
Publication status	Published - 12 Mar 1982
Externally published	Yes

Keywords

(Mouse)
Cholesterol
Lipid composition
Obesity
Phosphatide fatty acid

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/0005-2760(82)90111-4

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title = "Lipid composition in liver and brain of genetically obese (ob/ob), heterozygote (ob/+) and normal (+/+) mice",

abstract = "Lipid composition was studied in liver and brain of normal (+/+), heterozygote (ob/+) and obese (ob/ob) mice. It was found that this genetic defect is expressed differently in the lipid composition of these organs. Cholesterol is increased in liver but strongly decreased in brain of obese animals. Phosphatide fatty acid composition is modified in liver and not in brain. In contrast, phospholipids and total ganglioside sialic acid are affected similarly in both organs. Although clinically normal, heterozygote (ob/+) mice already show an abnormal lipid composition in liver and brain. The potential importance of these results is presented.",

keywords = "(Mouse), Cholesterol, Lipid composition, Obesity, Phosphatide fatty acid",

author = "Armando Sena and G{\'e}rard Rebel and Robert Bieth and Pierre Hubert and Albert Waksman",

note = "Funding Information: AS. is grateful to {\textquoteleft}Fundacao Calouste Gulbenkian{\textquoteright}. The authors are grateful to Mrs. Paulette Guerin and Marie-Claude Schickel for their technicala ssistancet,o Dr. C. Gardner for assistance in the linguistic revision of the manuscripta nd to Mrs. Claudine Thomassinf or careful typing of this paper.P art of this work was supportedb y the INSERM grant No. 803022b, y the FRMF and by the U.E.R. des Sciences BiomtdicalesU, .L.P. Strasbourg(L eg Ziring).G .R. and A.W. are Maitres de Recherche of the C.N.R.S.; P.H. is Attache de Recherche at I.N.S.E.R.M.",

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doi = "10.1016/0005-2760(82)90111-4",

language = "English",

volume = "710",

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journal = "Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids",

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TY - JOUR

T1 - Lipid composition in liver and brain of genetically obese (ob/ob), heterozygote (ob/+) and normal (+/+) mice

AU - Sena, Armando

AU - Rebel, Gérard

AU - Bieth, Robert

AU - Hubert, Pierre

AU - Waksman, Albert

N1 - Funding Information: AS. is grateful to ‘Fundacao Calouste Gulbenkian’. The authors are grateful to Mrs. Paulette Guerin and Marie-Claude Schickel for their technicala ssistancet,o Dr. C. Gardner for assistance in the linguistic revision of the manuscripta nd to Mrs. Claudine Thomassinf or careful typing of this paper.P art of this work was supportedb y the INSERM grant No. 803022b, y the FRMF and by the U.E.R. des Sciences BiomtdicalesU, .L.P. Strasbourg(L eg Ziring).G .R. and A.W. are Maitres de Recherche of the C.N.R.S.; P.H. is Attache de Recherche at I.N.S.E.R.M.

PY - 1982/3/12

Y1 - 1982/3/12

N2 - Lipid composition was studied in liver and brain of normal (+/+), heterozygote (ob/+) and obese (ob/ob) mice. It was found that this genetic defect is expressed differently in the lipid composition of these organs. Cholesterol is increased in liver but strongly decreased in brain of obese animals. Phosphatide fatty acid composition is modified in liver and not in brain. In contrast, phospholipids and total ganglioside sialic acid are affected similarly in both organs. Although clinically normal, heterozygote (ob/+) mice already show an abnormal lipid composition in liver and brain. The potential importance of these results is presented.

AB - Lipid composition was studied in liver and brain of normal (+/+), heterozygote (ob/+) and obese (ob/ob) mice. It was found that this genetic defect is expressed differently in the lipid composition of these organs. Cholesterol is increased in liver but strongly decreased in brain of obese animals. Phosphatide fatty acid composition is modified in liver and not in brain. In contrast, phospholipids and total ganglioside sialic acid are affected similarly in both organs. Although clinically normal, heterozygote (ob/+) mice already show an abnormal lipid composition in liver and brain. The potential importance of these results is presented.

KW - (Mouse)

KW - Cholesterol

KW - Lipid composition

KW - Obesity

KW - Phosphatide fatty acid

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DO - 10.1016/0005-2760(82)90111-4

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AN - SCOPUS:0020060156

SN - 0005-2760

VL - 710

SP - 290

EP - 296

JO - Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids

JF - Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids

IS - 3

ER -

Lipid composition in liver and brain of genetically obese (ob/ob), heterozygote (ob/+) and normal (+/+) mice

Abstract

Keywords

UN SDGs

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