Molecular epidemiological analysis of paired pol/env sequences from portuguese HIV type 1 patients

Ana B. Abecasis; Andreia Martins; Inês Costa; Ana P. Carvalho; Isabel Diogo; Perpétua Gomes; Ricardo J. Camacho

doi:10.1089/aid.2010.0312

Molecular epidemiological analysis of paired pol/env sequences from portuguese HIV type 1 patients

Ana B. Abecasis, Andreia Martins, Inês Costa, Ana P. Carvalho, Isabel Diogo, Perpétua Gomes, Ricardo J. Camacho

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

The advent of new therapeutic approaches targeting env and the search for efficient anti-HIV-1 vaccines make it necessary to identify the number of recombinant forms using genomic regions that were previously not frequently sequenced. In this study, we have subtyped paired pol and env sequences from HIV-1 strains infecting 152 patients being clinically followed in Portugal. The percentage of strains in which we found discordant subtypes in pol and env was 25.7%. When the subtype in pol and env was concordant (65.1%), the most prevalent subtypes were subtype B (40.8%), followed by subtype C (17.8%) and subtype G (5.3%). The most prevalent recombinant form was CRF14-BGpol/Genv (7.2%).

Original language	English
Pages (from-to)	803-805
Number of pages	3
Journal	AIDS Research and Human Retroviruses
Volume	27
Issue number	7
DOIs	https://doi.org/10.1089/aid.2010.0312
Publication status	Published - 1 Jul 2011
Externally published	Yes

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abstract = "The advent of new therapeutic approaches targeting env and the search for efficient anti-HIV-1 vaccines make it necessary to identify the number of recombinant forms using genomic regions that were previously not frequently sequenced. In this study, we have subtyped paired pol and env sequences from HIV-1 strains infecting 152 patients being clinically followed in Portugal. The percentage of strains in which we found discordant subtypes in pol and env was 25.7%. When the subtype in pol and env was concordant (65.1%), the most prevalent subtypes were subtype B (40.8%), followed by subtype C (17.8%) and subtype G (5.3%). The most prevalent recombinant form was CRF14-BGpol/Genv (7.2%).",

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AU - Abecasis, Ana B.

AU - Martins, Andreia

AU - Costa, Inês

AU - Carvalho, Ana P.

AU - Diogo, Isabel

AU - Gomes, Perpétua

AU - Camacho, Ricardo J.

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AB - The advent of new therapeutic approaches targeting env and the search for efficient anti-HIV-1 vaccines make it necessary to identify the number of recombinant forms using genomic regions that were previously not frequently sequenced. In this study, we have subtyped paired pol and env sequences from HIV-1 strains infecting 152 patients being clinically followed in Portugal. The percentage of strains in which we found discordant subtypes in pol and env was 25.7%. When the subtype in pol and env was concordant (65.1%), the most prevalent subtypes were subtype B (40.8%), followed by subtype C (17.8%) and subtype G (5.3%). The most prevalent recombinant form was CRF14-BGpol/Genv (7.2%).

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Molecular epidemiological analysis of paired pol/env sequences from portuguese HIV type 1 patients

Abstract

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