TY - JOUR
T1 - Phase angle as a key marker of muscular and bone quality in community-dwelling independent older adults
T2 - A cross-sectional exploratory pilot study
AU - Duarte Martins, Alexandre
AU - Paulo Brito, João
AU - Batalha, Nuno
AU - Oliveira, Rafael
AU - Parraca, Jose A.
AU - Fernandes, Orlando
N1 - Funding Information:
This research was funded by the Fundação para a Ciência e a Tecnologia , I.P., Grant/Award Numbers 2021.04598.BD ; UIDP/04923/2020 and UIDP/04748/2020 . The funders had no role in the design of the study; in the collection, analyses or interpretation of data; in the writing of the manuscript or in the decision to publish the results.
Funding Information:
This research was funded by the Fundação para a Ciência e a Tecnologia, I.P., Grant/Award Numbers 2021.04598.BD; UIDP/04923/2020 and UIDP/04748/2020. The funders had no role in the design of the study; in the collection, analyses or interpretation of data; in the writing of the manuscript or in the decision to publish the results.
Publisher Copyright:
© 2023
© 2023 The Authors.
PY - 2023/7
Y1 - 2023/7
N2 - The aim of the present cross-sectional exploratory pilot study was to analyze the ability of the Phase Angle (PhA) to predict physical function, muscle strength and bone indicators, upon adjusting for potential confounders [age, sex, lean mass, and body mass index (BMI)]. This study included 56 physically independent older adults (age, 68.29 ± 3.01 years; BMI, 28.09 ± 4.37 kg/m2). A multi-frequency segmental bioelectrical impedance analysis was used to measure PhA at 50 KHz. Additionally, physical function was assessed through four functional capacity tests [30-sec chair‐stand; seated medicine ball throw (SMBT); timed up & go; and 6-min walking test (6 MWT)], muscle strength through the handgrip test (dominant side) and maximal isokinetic strength of the dominant knee flexor and extensor. Moreover, bone indicators and body composition were assessed through the dual energy X-ray absorptiometry. PhA was significantly associated with SMBT (r = 0.375, effect size (ES) = moderate); 6 MWT (r = 0.396, ES = moderate); 30-sec chair‐stand (rho = 0.314, ES = moderate); knee extension (rho = 0.566, ES = large) and flexion (r = 0.459, ES = moderate); handgrip (rho = 0.432, ES = moderate); whole-body bone mineral content (BMC) (r = 0.316, ES = moderate); femoral neck BMC (r = 0.469, ES = moderate); and femoral neck bone mineral density (BMD) (rho = 0.433, ES = moderate). Additionally, the results of multiple regression analysis demonstrated that PhA is significantly associated with SMBT (p < 0.001; R2 = 0.629), 6 MWT (p = 0.004; R2 = 0.214), knee extension (p < 0.001; R2 = 0.697), knee flexion (p < 0.001; R2 = 0.355), handgrip test (p < 0.001; R2 = 0.774), whole-body BMC (p < 0.001; R2 = 0.524), femoral neck BMC (p = 0.001; R2 = 0.249), and femoral neck BMD (p = 0.020; R2 = 0.153). The results of the preliminary analysis suggested that PhA is linked to muscle strength and some factors related to physical function and bone quality in community-dwelling older adults.
AB - The aim of the present cross-sectional exploratory pilot study was to analyze the ability of the Phase Angle (PhA) to predict physical function, muscle strength and bone indicators, upon adjusting for potential confounders [age, sex, lean mass, and body mass index (BMI)]. This study included 56 physically independent older adults (age, 68.29 ± 3.01 years; BMI, 28.09 ± 4.37 kg/m2). A multi-frequency segmental bioelectrical impedance analysis was used to measure PhA at 50 KHz. Additionally, physical function was assessed through four functional capacity tests [30-sec chair‐stand; seated medicine ball throw (SMBT); timed up & go; and 6-min walking test (6 MWT)], muscle strength through the handgrip test (dominant side) and maximal isokinetic strength of the dominant knee flexor and extensor. Moreover, bone indicators and body composition were assessed through the dual energy X-ray absorptiometry. PhA was significantly associated with SMBT (r = 0.375, effect size (ES) = moderate); 6 MWT (r = 0.396, ES = moderate); 30-sec chair‐stand (rho = 0.314, ES = moderate); knee extension (rho = 0.566, ES = large) and flexion (r = 0.459, ES = moderate); handgrip (rho = 0.432, ES = moderate); whole-body bone mineral content (BMC) (r = 0.316, ES = moderate); femoral neck BMC (r = 0.469, ES = moderate); and femoral neck bone mineral density (BMD) (rho = 0.433, ES = moderate). Additionally, the results of multiple regression analysis demonstrated that PhA is significantly associated with SMBT (p < 0.001; R2 = 0.629), 6 MWT (p = 0.004; R2 = 0.214), knee extension (p < 0.001; R2 = 0.697), knee flexion (p < 0.001; R2 = 0.355), handgrip test (p < 0.001; R2 = 0.774), whole-body BMC (p < 0.001; R2 = 0.524), femoral neck BMC (p = 0.001; R2 = 0.249), and femoral neck BMD (p = 0.020; R2 = 0.153). The results of the preliminary analysis suggested that PhA is linked to muscle strength and some factors related to physical function and bone quality in community-dwelling older adults.
KW - Aging
KW - Bioelectrical impedance analysis
KW - Bone mineral density
KW - Elderly
KW - Functional capacity
KW - Skeleton
UR - http://www.scopus.com/inward/record.url?scp=85163453721&partnerID=8YFLogxK
U2 - 10.1016/j.heliyon.2023.e17593
DO - 10.1016/j.heliyon.2023.e17593
M3 - Article
C2 - 37539181
AN - SCOPUS:85163453721
SN - 2405-8440
VL - 9
SP - e17593
JO - Heliyon
JF - Heliyon
IS - 7
M1 - e17593
ER -