Abstract
Potent HIV-neutralizing antibodies are critical for vaccination and viral reservoir control. High levels of neutralizing antibodies characterize HIV-2 infection, a naturally occurring model of attenuated HIV disease with low-to-undectable viremia. We found that HIV-2-specific antibody potency increased in direct association with the loss of both switched and unswitched memory B cells in untreated HIV-2 infection. Thus, HIV antibody affinity maturation is linked to memory B-cell exhaustion even in reduced viremia settings.
Original language | English |
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Pages (from-to) | 2431-2433 |
Number of pages | 3 |
Journal | AIDS |
Volume | 31 |
Issue number | 17 |
DOIs | |
Publication status | Published - 13 Nov 2017 |