Potency of HIV-2-specific antibodies increase in direct association with loss of memory B cells

Cheila Rocha; Joana Duarte; Pedro Borrego; Rita Calado; José Maria Marcelino; Rita Tendeiro; Emília Valadas; Ana Espada Sousa; Nuno Taveira

doi:10.1097/QAD.0000000000001661

Potency of HIV-2-specific antibodies increase in direct association with loss of memory B cells

Cheila Rocha
, Joana Duarte
, Pedro Borrego
, Rita Calado
, José Maria Marcelino
, Rita Tendeiro
, Emília Valadas
, Ana Espada Sousa
, Nuno Taveira

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

Potent HIV-neutralizing antibodies are critical for vaccination and viral reservoir control. High levels of neutralizing antibodies characterize HIV-2 infection, a naturally occurring model of attenuated HIV disease with low-to-undectable viremia. We found that HIV-2-specific antibody potency increased in direct association with the loss of both switched and unswitched memory B cells in untreated HIV-2 infection. Thus, HIV antibody affinity maturation is linked to memory B-cell exhaustion even in reduced viremia settings.

Original language	English
Pages (from-to)	2431-2433
Number of pages	3
Journal	AIDS
Volume	31
Issue number	17
DOIs	https://doi.org/10.1097/QAD.0000000000001661
Publication status	Published - 13 Nov 2017

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10.1097/QAD.0000000000001661

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title = "Potency of HIV-2-specific antibodies increase in direct association with loss of memory B cells",

abstract = "Potent HIV-neutralizing antibodies are critical for vaccination and viral reservoir control. High levels of neutralizing antibodies characterize HIV-2 infection, a naturally occurring model of attenuated HIV disease with low-to-undectable viremia. We found that HIV-2-specific antibody potency increased in direct association with the loss of both switched and unswitched memory B cells in untreated HIV-2 infection. Thus, HIV antibody affinity maturation is linked to memory B-cell exhaustion even in reduced viremia settings.",

author = "Cheila Rocha and Joana Duarte and Pedro Borrego and Rita Calado and Marcelino, \{Jos{\'e} Maria\} and Rita Tendeiro and Em{\'i}lia Valadas and Sousa, \{Ana Espada\} and Nuno Taveira",

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doi = "10.1097/QAD.0000000000001661",

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TY - JOUR

T1 - Potency of HIV-2-specific antibodies increase in direct association with loss of memory B cells

AU - Rocha, Cheila

AU - Duarte, Joana

AU - Borrego, Pedro

AU - Calado, Rita

AU - Marcelino, José Maria

AU - Tendeiro, Rita

AU - Valadas, Emília

AU - Sousa, Ana Espada

AU - Taveira, Nuno

PY - 2017/11/13

Y1 - 2017/11/13

N2 - Potent HIV-neutralizing antibodies are critical for vaccination and viral reservoir control. High levels of neutralizing antibodies characterize HIV-2 infection, a naturally occurring model of attenuated HIV disease with low-to-undectable viremia. We found that HIV-2-specific antibody potency increased in direct association with the loss of both switched and unswitched memory B cells in untreated HIV-2 infection. Thus, HIV antibody affinity maturation is linked to memory B-cell exhaustion even in reduced viremia settings.

AB - Potent HIV-neutralizing antibodies are critical for vaccination and viral reservoir control. High levels of neutralizing antibodies characterize HIV-2 infection, a naturally occurring model of attenuated HIV disease with low-to-undectable viremia. We found that HIV-2-specific antibody potency increased in direct association with the loss of both switched and unswitched memory B cells in untreated HIV-2 infection. Thus, HIV antibody affinity maturation is linked to memory B-cell exhaustion even in reduced viremia settings.

UR - https://www.scopus.com/pages/publications/85034061405

U2 - 10.1097/QAD.0000000000001661

DO - 10.1097/QAD.0000000000001661

M3 - Article

C2 - 29028655

AN - SCOPUS:85034061405

SN - 0269-9370

VL - 31

SP - 2431

EP - 2433

JO - AIDS

JF - AIDS

IS - 17

ER -

Potency of HIV-2-specific antibodies increase in direct association with loss of memory B cells

Abstract

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