TY - JOUR
T1 - Predictors of positive axillary lymph nodes in breast cancer patients with metastatic sentinel lymph node
AU - Callejo, Isabel Peixoto
AU - Brito, José Américo
AU - Bivar, José Wheinholtz
AU - Fernandes, Fernando Jesus
AU - Fariaa, João Leal
AU - André, María Saudade
AU - Costaa, Carlos Santos
AU - Almeida, M. Odette
AU - Sousaa, J. Meneses E.
PY - 2005/1
Y1 - 2005/1
N2 - Introduction. Breast cancer with metastatic sentinel lymph nodes (SLN) may have clinico-pathologic factors associated with the presence of positive nonsentinel axillary nodes (NSLN). The aim of the present study was to determine factors that predict involvement of NSLN in breast cancer patients with positive SLN. Material and methods. A prospective database search identified 80 patients who underwent SLN biopsy for invasive breast cancer between January 1999 and August 2002. Clinico-pathologic data was analyzed to determine factors that predicted additional positive axillary nodes. Results. A total of 23 patients had positive SLN and underwent conventional axillary lymph node dissection. Statistical analysis revealed that lymphovascular invasion (p~0.00000), SLN metastasis >2 mm (p=0.002), and the presence of extra-nodal involvement (p=0.002), were positive predictors of the metastatic involvement of NSLN. Conclusions. The likelihood of positive NSLN correlates with pathologic parameters such as the presence of lympho-vascular invasion, size of the SLN metastasis, and extra-nodal involvement. These data may be helpful with the regard to the decision to undertake axillary dissection in breast cancer patients with metastatic sentinel lymph nodes.
AB - Introduction. Breast cancer with metastatic sentinel lymph nodes (SLN) may have clinico-pathologic factors associated with the presence of positive nonsentinel axillary nodes (NSLN). The aim of the present study was to determine factors that predict involvement of NSLN in breast cancer patients with positive SLN. Material and methods. A prospective database search identified 80 patients who underwent SLN biopsy for invasive breast cancer between January 1999 and August 2002. Clinico-pathologic data was analyzed to determine factors that predicted additional positive axillary nodes. Results. A total of 23 patients had positive SLN and underwent conventional axillary lymph node dissection. Statistical analysis revealed that lymphovascular invasion (p~0.00000), SLN metastasis >2 mm (p=0.002), and the presence of extra-nodal involvement (p=0.002), were positive predictors of the metastatic involvement of NSLN. Conclusions. The likelihood of positive NSLN correlates with pathologic parameters such as the presence of lympho-vascular invasion, size of the SLN metastasis, and extra-nodal involvement. These data may be helpful with the regard to the decision to undertake axillary dissection in breast cancer patients with metastatic sentinel lymph nodes.
KW - Axilla dissection
KW - Breast cancer
KW - Clinico-pathologic predictors
KW - Sentinel lymph node
UR - http://www.scopus.com/inward/record.url?scp=22244474318&partnerID=8YFLogxK
U2 - 10.1007/BF02710021
DO - 10.1007/BF02710021
M3 - Article
C2 - 15890151
AN - SCOPUS:22244474318
SN - 1699-048X
VL - 7
SP - 18
EP - 22
JO - Clinical and Translational Oncology
JF - Clinical and Translational Oncology
IS - 1
ER -
