TY - JOUR
T1 - Preserved CD4 T-cell telomere length during long-lasting HIV-2 infection
AU - Tendeiro, Rita
AU - Albuquerque, Adriana S.
AU - Foxall, Russell B.
AU - Cavaleiro, Rita
AU - Soares, Rui S.
AU - Baptista, António P.
AU - Soares, Maria V.D.
AU - Gomes, Perpétua
AU - Sousa, Ana E.
PY - 2013/1/14
Y1 - 2013/1/14
N2 - HIV-2 infection features a much slower course than HIV-1 infection, often asymptomatic for over 20 years, without antiretroviral therapy (ART). Nevertheless, CD4 T cells progressively decline, in direct correlation with immune activation and cell cycling. We report, for the first time, preserved telomere length within naive and memory CD4 subsets in prolonged HIV-2 infection despite the increased CD4 turnover.
AB - HIV-2 infection features a much slower course than HIV-1 infection, often asymptomatic for over 20 years, without antiretroviral therapy (ART). Nevertheless, CD4 T cells progressively decline, in direct correlation with immune activation and cell cycling. We report, for the first time, preserved telomere length within naive and memory CD4 subsets in prolonged HIV-2 infection despite the increased CD4 turnover.
UR - http://www.scopus.com/inward/record.url?scp=84872416149&partnerID=8YFLogxK
U2 - 10.1097/QAD.0b013e32835ab234
DO - 10.1097/QAD.0b013e32835ab234
M3 - Article
C2 - 23032416
AN - SCOPUS:84872416149
SN - 0269-9370
VL - 27
SP - 289
EP - 292
JO - AIDS
JF - AIDS
IS - 2
ER -
