Preserved CD4 T-cell telomere length during long-lasting HIV-2 infection

Rita Tendeiro; Adriana S. Albuquerque; Russell B. Foxall; Rita Cavaleiro; Rui S. Soares; António P. Baptista; Maria V.D. Soares; Perpétua Gomes; Ana E. Sousa

doi:10.1097/QAD.0b013e32835ab234

Preserved CD4 T-cell telomere length during long-lasting HIV-2 infection

Rita Tendeiro
, Adriana S. Albuquerque
, Russell B. Foxall
, Rita Cavaleiro
, Rui S. Soares
, António P. Baptista
, Maria V.D. Soares
, Perpétua Gomes
, Ana E. Sousa

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

HIV-2 infection features a much slower course than HIV-1 infection, often asymptomatic for over 20 years, without antiretroviral therapy (ART). Nevertheless, CD4 T cells progressively decline, in direct correlation with immune activation and cell cycling. We report, for the first time, preserved telomere length within naive and memory CD4 subsets in prolonged HIV-2 infection despite the increased CD4 turnover.

Original language	English
Pages (from-to)	289-292
Number of pages	4
Journal	AIDS
Volume	27
Issue number	2
DOIs	https://doi.org/10.1097/QAD.0b013e32835ab234
Publication status	Published - 14 Jan 2013

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SDG 3 Good Health and Well-being

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10.1097/QAD.0b013e32835ab234

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title = "Preserved CD4 T-cell telomere length during long-lasting HIV-2 infection",

abstract = "HIV-2 infection features a much slower course than HIV-1 infection, often asymptomatic for over 20 years, without antiretroviral therapy (ART). Nevertheless, CD4 T cells progressively decline, in direct correlation with immune activation and cell cycling. We report, for the first time, preserved telomere length within naive and memory CD4 subsets in prolonged HIV-2 infection despite the increased CD4 turnover.",

author = "Rita Tendeiro and Albuquerque, \{Adriana S.\} and Foxall, \{Russell B.\} and Rita Cavaleiro and Soares, \{Rui S.\} and Baptista, \{Ant{\'o}nio P.\} and Soares, \{Maria V.D.\} and Perp{\'e}tua Gomes and Sousa, \{Ana E.\}",

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doi = "10.1097/QAD.0b013e32835ab234",

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TY - JOUR

T1 - Preserved CD4 T-cell telomere length during long-lasting HIV-2 infection

AU - Tendeiro, Rita

AU - Albuquerque, Adriana S.

AU - Foxall, Russell B.

AU - Cavaleiro, Rita

AU - Soares, Rui S.

AU - Baptista, António P.

AU - Soares, Maria V.D.

AU - Gomes, Perpétua

AU - Sousa, Ana E.

PY - 2013/1/14

Y1 - 2013/1/14

N2 - HIV-2 infection features a much slower course than HIV-1 infection, often asymptomatic for over 20 years, without antiretroviral therapy (ART). Nevertheless, CD4 T cells progressively decline, in direct correlation with immune activation and cell cycling. We report, for the first time, preserved telomere length within naive and memory CD4 subsets in prolonged HIV-2 infection despite the increased CD4 turnover.

AB - HIV-2 infection features a much slower course than HIV-1 infection, often asymptomatic for over 20 years, without antiretroviral therapy (ART). Nevertheless, CD4 T cells progressively decline, in direct correlation with immune activation and cell cycling. We report, for the first time, preserved telomere length within naive and memory CD4 subsets in prolonged HIV-2 infection despite the increased CD4 turnover.

UR - https://www.scopus.com/pages/publications/84872416149

U2 - 10.1097/QAD.0b013e32835ab234

DO - 10.1097/QAD.0b013e32835ab234

M3 - Article

C2 - 23032416

AN - SCOPUS:84872416149

SN - 0269-9370

VL - 27

SP - 289

EP - 292

JO - AIDS

JF - AIDS

IS - 2

ER -

Preserved CD4 T-cell telomere length during long-lasting HIV-2 infection

Abstract

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