Prevention of Photocarcinogenesis by Agonists of 5-HT1A and Antagonists of 5-HT2A Receptors

Ana Catarina Menezes, Sara Raposo, Sandra Simões, Helena Ribeiro, Helena Oliveira, Andreia Ascenso

Research output: Contribution to journalReview articlepeer-review

12 Citations (Scopus)

Abstract

Exposure to UV radiation is the principal cause of nonmelanoma skin cancer, a process in which serotonin (5-HT) is intimately involved. This review focuses on the potential of serotonin receptors, namely 5-HT1/2A, as therapeutic targets for prevention of photocarcinogenesis. UV-induced immunosuppression is triggered by a cascade of events initiated when cis-urocanic acid, a UV photoreceptor present in the skin, binds to the serotonin receptor. Serotonin receptor antagonists will therefore attempt to block this association, and in turn, prevent skin cancer induction. In addition, 5-HT2A receptor antagonists are also capable of regulating DNA repair, including the acceleration of nucleotide excision repair. At the same time, UV-induced formation of reactive oxygen species is also reduced by these agents. Since the involvement of serotonin in photocarcinogenesis process is somewhat underexplored as a pertinent therapeutic effect, this review intends to reveal the use of serotonergic drugs as an important strategy to prevent and/or inhibit photocarcinogenesis. Considering the emergency of developing novel therapeutic strategies for skin cancer management, the use of these agents, whose benefits have partially been studied, may be crucial especially if topically applied. Topical nanoformulations containing serotonin receptor agonists and/or antagonists also represent a pioneer concept in this area. [Figure not available: see fulltext.]

Original languageEnglish
Pages (from-to)1145-1164
Number of pages20
JournalMolecular Neurobiology
Volume53
Issue number2
DOIs
Publication statusPublished - 1 Mar 2016
Externally publishedYes

Keywords

  • DNA repair and cells proliferation
  • Immunomodulation
  • Photocarcinogenesis
  • Serotonin
  • Serotonin receptors agonists and antagonists

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