Prevention of skin lesions caused by the use of protective face masks by an innovative gelatin-based hydrogel patch: Design and in vitro studies

Angélica Graça, Ismael Rufino, Ana M. Martins, Sara Raposo, Helena M. Ribeiro, Joana Marto

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

The recent Covid-19 pandemics led to the increased use of facial masks, which can cause skin lesions due to continuous pressure, tension and friction forces on the skin. A preventive approach is the inclusion of dressings between the face and the mask. However, there are still uncertainties about the protective effect of dressings and whether their use compromises the efficiency of masks. The current study aimed to develop and test the efficacy of a gelatin-based hydrogel patch to be placed between the mask and the facial area. Design of Experiment with a Quality by Design approach tools were used in the patch development and in vitro characterization was performed through rheological evaluation, ATR-FTIR and molecular docking studies. Furthermore, tribology studies were performed to test the patch performance. The results showed that the addition of excipients enhanced gelation temperature, elasticity and adhesiveness parameters. The interactions between excipients were confirmed by ATR-FTIR and molecular docking. The tribology assay revealed similar friction values at room and physiological temperature, and when testing different skin types. In conclusion, the physical properties and the performance evaluation reported in this study indicate that this innovative film-forming system can be used to prevent skin lesions caused by the continuous use of protective masks.

Original languageEnglish
Article number122941
Pages (from-to)122941
JournalInternational Journal of Pharmaceutics
Volume638
DOIs
Publication statusPublished - 10 May 2023
Externally publishedYes

Keywords

  • Hydrogel
  • In vitro performance studies
  • Molecular docking
  • QbD
  • Tribology
  • Excipients
  • Hydrogels
  • Humans
  • Skin Diseases
  • Masks
  • Gelatin
  • COVID-19/prevention & control
  • Molecular Docking Simulation

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