Prognostic value of unrelated atypical serum immunofixation patterns during Multiple Myeloma therapy

Cristina Guimarães; Rui Bergantim; Renata Ramalho; Nuno Couto; João T. Guimarães; Fernanda Trigo

doi:10.1186/1756-8722-5-33

Prognostic value of unrelated atypical serum immunofixation patterns during Multiple Myeloma therapy

Cristina Guimarães, Rui Bergantim, Renata Ramalho, Nuno Couto, João T. Guimarães, Fernanda Trigo

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

Autologous stem cell transplantation (ASCT) is the gold standard therapy for suitable multiple myeloma (MM) patients after induction with high dose therapy. To date, the evidence of a reliable marker of prognosis in these cases remains scarce. Our aim was to evaluate appearance of unrelated atypical serum immunofixation patterns (ASIPs) as a marker of prognosis in MM patients submitted to ASCT. We retrospectively analysed data from 65 patients. Interestingly, we observed that presence of ASIPs was associated with longer progression-free survival and longer overall survival. Our results suggested that presence of ASIPs could be a novel marker of good prognosis in MM patients submitted to ASCT.

Original language	English
Article number	33
Journal	Journal of Hematology and Oncology
Volume	5
DOIs	https://doi.org/10.1186/1756-8722-5-33
Publication status	Published - 2012
Externally published	Yes

Keywords

Autologous stem cell transplantation
Marker of prognosis
Multiple myeloma
Serum immunofixation patterns

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1186/1756-8722-5-33

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title = "Prognostic value of unrelated atypical serum immunofixation patterns during Multiple Myeloma therapy",

abstract = "Autologous stem cell transplantation (ASCT) is the gold standard therapy for suitable multiple myeloma (MM) patients after induction with high dose therapy. To date, the evidence of a reliable marker of prognosis in these cases remains scarce. Our aim was to evaluate appearance of unrelated atypical serum immunofixation patterns (ASIPs) as a marker of prognosis in MM patients submitted to ASCT. We retrospectively analysed data from 65 patients. Interestingly, we observed that presence of ASIPs was associated with longer progression-free survival and longer overall survival. Our results suggested that presence of ASIPs could be a novel marker of good prognosis in MM patients submitted to ASCT.",

keywords = "Autologous stem cell transplantation, Marker of prognosis, Multiple myeloma, Serum immunofixation patterns",

author = "Cristina Guimar{\~a}es and Rui Bergantim and Renata Ramalho and Nuno Couto and Guimar{\~a}es, {Jo{\~a}o T.} and Fernanda Trigo",

year = "2012",

doi = "10.1186/1756-8722-5-33",

language = "English",

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journal = "Journal of Hematology and Oncology",

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T1 - Prognostic value of unrelated atypical serum immunofixation patterns during Multiple Myeloma therapy

AU - Guimarães, Cristina

AU - Bergantim, Rui

AU - Ramalho, Renata

AU - Couto, Nuno

AU - Guimarães, João T.

AU - Trigo, Fernanda

PY - 2012

Y1 - 2012

N2 - Autologous stem cell transplantation (ASCT) is the gold standard therapy for suitable multiple myeloma (MM) patients after induction with high dose therapy. To date, the evidence of a reliable marker of prognosis in these cases remains scarce. Our aim was to evaluate appearance of unrelated atypical serum immunofixation patterns (ASIPs) as a marker of prognosis in MM patients submitted to ASCT. We retrospectively analysed data from 65 patients. Interestingly, we observed that presence of ASIPs was associated with longer progression-free survival and longer overall survival. Our results suggested that presence of ASIPs could be a novel marker of good prognosis in MM patients submitted to ASCT.

AB - Autologous stem cell transplantation (ASCT) is the gold standard therapy for suitable multiple myeloma (MM) patients after induction with high dose therapy. To date, the evidence of a reliable marker of prognosis in these cases remains scarce. Our aim was to evaluate appearance of unrelated atypical serum immunofixation patterns (ASIPs) as a marker of prognosis in MM patients submitted to ASCT. We retrospectively analysed data from 65 patients. Interestingly, we observed that presence of ASIPs was associated with longer progression-free survival and longer overall survival. Our results suggested that presence of ASIPs could be a novel marker of good prognosis in MM patients submitted to ASCT.

KW - Autologous stem cell transplantation

KW - Marker of prognosis

KW - Multiple myeloma

KW - Serum immunofixation patterns

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U2 - 10.1186/1756-8722-5-33

DO - 10.1186/1756-8722-5-33

M3 - Article

C2 - 22734892

AN - SCOPUS:84865440214

SN - 1756-8722

VL - 5

JO - Journal of Hematology and Oncology

JF - Journal of Hematology and Oncology

M1 - 33

ER -

Prognostic value of unrelated atypical serum immunofixation patterns during Multiple Myeloma therapy

Abstract

Keywords

UN SDGs

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