Rapid clinical progression to AIDS and death in a persistently seronegative HIV-1 infected heterosexual young man

Inês Bártolo, Ricardo Camacho, Helena Barroso, Victor Bezerra, Nuno Taveira

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

Seronegative HIV-1 infection has important implications for diagnosis and prevention. We describe a case of HIV-1 infection without seroconversion and fast progression to AIDS and death. Genetic and phylogenetic analysis indicated that the patient was infected with a CRF14-BG-like strain selectively transmitted by his seropositive sexual partner. The results suggest a massive infection with a highly aggressive CRF14-BG-like strain and/or the presence of an unidentified immunological deficiency that has prevented the formation of HIV-1-specific antibodies.

Original languageEnglish
Pages (from-to)2359-2362
Number of pages4
JournalAIDS
Volume23
Issue number17
DOIs
Publication statusPublished - Nov 2009

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