Rapid clinical progression to AIDS and death in a persistently seronegative HIV-1 infected heterosexual young man

Inês Bártolo; Ricardo Camacho; Helena Barroso; Victor Bezerra; Nuno Taveira

doi:10.1097/QAD.0b013e328332d5e1

Rapid clinical progression to AIDS and death in a persistently seronegative HIV-1 infected heterosexual young man

Inês Bártolo, Ricardo Camacho, Helena Barroso, Victor Bezerra, Nuno Taveira

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

Seronegative HIV-1 infection has important implications for diagnosis and prevention. We describe a case of HIV-1 infection without seroconversion and fast progression to AIDS and death. Genetic and phylogenetic analysis indicated that the patient was infected with a CRF14-BG-like strain selectively transmitted by his seropositive sexual partner. The results suggest a massive infection with a highly aggressive CRF14-BG-like strain and/or the presence of an unidentified immunological deficiency that has prevented the formation of HIV-1-specific antibodies.

Original language	English
Pages (from-to)	2359-2362
Number of pages	4
Journal	AIDS
Volume	23
Issue number	17
DOIs	https://doi.org/10.1097/QAD.0b013e328332d5e1
Publication status	Published - Nov 2009

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10.1097/QAD.0b013e328332d5e1

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AU - Bártolo, Inês

AU - Camacho, Ricardo

AU - Barroso, Helena

AU - Bezerra, Victor

AU - Taveira, Nuno

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AB - Seronegative HIV-1 infection has important implications for diagnosis and prevention. We describe a case of HIV-1 infection without seroconversion and fast progression to AIDS and death. Genetic and phylogenetic analysis indicated that the patient was infected with a CRF14-BG-like strain selectively transmitted by his seropositive sexual partner. The results suggest a massive infection with a highly aggressive CRF14-BG-like strain and/or the presence of an unidentified immunological deficiency that has prevented the formation of HIV-1-specific antibodies.

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Rapid clinical progression to AIDS and death in a persistently seronegative HIV-1 infected heterosexual young man

Abstract

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