TY - JOUR
T1 - Recent progress in the field of glycoconjugates
AU - Crucho, Carina I.C.
AU - Correia-Da-Silva, Paula
AU - Petrova, Krasimira T.
AU - Barros, M. Teresa
PY - 2015/1/30
Y1 - 2015/1/30
N2 - The ubiquity of glycoconjugates in nature and their role in different biological processes, has led to the development of several methodologies to synthesize these molecules. Synthetic glycoconjugates are now used to answer a variety of glycoconjugate-related biological questions and have provided new potential vaccines against cancer, viral, and bacterial infections and new biotechnological tools. This review aims to collect and compile the recent advances in the field of glycopeptides, glycoproteins, and glycolipid synthesis and also to update the previous reviews made on this subject. Finally, by highlighting the successes and failures of past research, we hope that this review will inspire fruitful research in this important medicinal chemistry field.
AB - The ubiquity of glycoconjugates in nature and their role in different biological processes, has led to the development of several methodologies to synthesize these molecules. Synthetic glycoconjugates are now used to answer a variety of glycoconjugate-related biological questions and have provided new potential vaccines against cancer, viral, and bacterial infections and new biotechnological tools. This review aims to collect and compile the recent advances in the field of glycopeptides, glycoproteins, and glycolipid synthesis and also to update the previous reviews made on this subject. Finally, by highlighting the successes and failures of past research, we hope that this review will inspire fruitful research in this important medicinal chemistry field.
KW - Carbohydrates
KW - Glycobiology
KW - Glycoconjugates
UR - http://www.scopus.com/inward/record.url?scp=84919625198&partnerID=8YFLogxK
U2 - 10.1016/j.carres.2014.10.005
DO - 10.1016/j.carres.2014.10.005
M3 - Review article
C2 - 25498012
AN - SCOPUS:84919625198
SN - 0008-6215
VL - 402
SP - 124
EP - 132
JO - Carbohydrate Research
JF - Carbohydrate Research
ER -
