Sapwood of carob tree (Ceratonia siliqua L.) as a potential source of bioactive compounds

Luísa Custódio; Ana Luísa Escapa; João Patarra; Rosa Aligué; Fernando Alberício; Nuno Rosa Neng; José Manuel Florêncio Nogueira; Anabela Romano

Sapwood of carob tree (Ceratonia siliqua L.) as a potential source of bioactive compounds

Luísa Custódio, Ana Luísa Escapa, João Patarra, Rosa Aligué, Fernando Alberício, Nuno Rosa Neng, José Manuel Florêncio Nogueira, Anabela Romano

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

Methanol (ME) and hot water extracts (WE) of carob tree sapwood (Ceratonia siliqua L.) exhibited high antioxidant activity and were rich in phenolic compounds, with the main compounds identified by HPLC/DAD as gentisic acid and (-)-epicatechin. The ME displayed a high in vitro antitumor activity against human tumoural cell lines and reduced intracellular ROS production by HeLa cells after treatment with H2O2. (-)-Epicatechin was shown to contribute to the cytotoxic activity of the ME. This is the first report on the biological activity of carob tree sapwood.

Original language	English
Pages (from-to)	225-229
Number of pages	5
Journal	Records of Natural Products
Volume	7
Issue number	3
Publication status	Published - 28 May 2013
Externally published	Yes

Keywords

Antioxidant activity
Cytotoxic
Gentisic acid
Phenolic compounds
ROS

Cite this

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abstract = "Methanol (ME) and hot water extracts (WE) of carob tree sapwood (Ceratonia siliqua L.) exhibited high antioxidant activity and were rich in phenolic compounds, with the main compounds identified by HPLC/DAD as gentisic acid and (-)-epicatechin. The ME displayed a high in vitro antitumor activity against human tumoural cell lines and reduced intracellular ROS production by HeLa cells after treatment with H2O2. (-)-Epicatechin was shown to contribute to the cytotoxic activity of the ME. This is the first report on the biological activity of carob tree sapwood.",

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AU - Custódio, Luísa

AU - Escapa, Ana Luísa

AU - Patarra, João

AU - Aligué, Rosa

AU - Alberício, Fernando

AU - Neng, Nuno Rosa

AU - Florêncio Nogueira, José Manuel

AU - Romano, Anabela

PY - 2013/5/28

Y1 - 2013/5/28

N2 - Methanol (ME) and hot water extracts (WE) of carob tree sapwood (Ceratonia siliqua L.) exhibited high antioxidant activity and were rich in phenolic compounds, with the main compounds identified by HPLC/DAD as gentisic acid and (-)-epicatechin. The ME displayed a high in vitro antitumor activity against human tumoural cell lines and reduced intracellular ROS production by HeLa cells after treatment with H2O2. (-)-Epicatechin was shown to contribute to the cytotoxic activity of the ME. This is the first report on the biological activity of carob tree sapwood.

AB - Methanol (ME) and hot water extracts (WE) of carob tree sapwood (Ceratonia siliqua L.) exhibited high antioxidant activity and were rich in phenolic compounds, with the main compounds identified by HPLC/DAD as gentisic acid and (-)-epicatechin. The ME displayed a high in vitro antitumor activity against human tumoural cell lines and reduced intracellular ROS production by HeLa cells after treatment with H2O2. (-)-Epicatechin was shown to contribute to the cytotoxic activity of the ME. This is the first report on the biological activity of carob tree sapwood.

KW - Antioxidant activity

KW - Cytotoxic

KW - Gentisic acid

KW - Phenolic compounds

KW - ROS

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SN - 1307-6167

VL - 7

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JO - Records of Natural Products

JF - Records of Natural Products

IS - 3

ER -

Sapwood of carob tree (Ceratonia siliqua L.) as a potential source of bioactive compounds

Abstract

Keywords

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