Seronegative infection and AIDS caused by an A2 subsubtype HIV-1

Ana R. Cardoso; Cristina Gonçalves; Dulce Pascoalinho; Carla Gil; António F. Ferreira; Inês Bártolo; Nuno Taveira

doi:10.1097/00002030-200404300-00018

Seronegative infection and AIDS caused by an A2 subsubtype HIV-1

Ana R. Cardoso, Cristina Gonçalves, Dulce Pascoalinho, Carla Gil, António F. Ferreira, Inês Bártolo, Nuno Taveira

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

The study of true seronegative HIV-1 infections may have important implications for the diagnosis and prevention of HIV-1 infection. The case of an AIDS patient with persistently negative HIV serology is described. Genetic and phylogenetic analysis indicated that she was infected with an A2 subsubtype HIV-1 transmitted by her seropositive and asymptomatic sexual partner. The clinical and serological discordant results suggest the presence of an immunological deficiency that prevents the formation of HIV-1-specific antibodies.

Original language	English
Pages (from-to)	1071-1074
Number of pages	4
Journal	AIDS
Volume	18
Issue number	7
DOIs	https://doi.org/10.1097/00002030-200404300-00018
Publication status	Published - 30 Apr 2004

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AU - Cardoso, Ana R.

AU - Gonçalves, Cristina

AU - Pascoalinho, Dulce

AU - Gil, Carla

AU - Ferreira, António F.

AU - Bártolo, Inês

AU - Taveira, Nuno

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AB - The study of true seronegative HIV-1 infections may have important implications for the diagnosis and prevention of HIV-1 infection. The case of an AIDS patient with persistently negative HIV serology is described. Genetic and phylogenetic analysis indicated that she was infected with an A2 subsubtype HIV-1 transmitted by her seropositive and asymptomatic sexual partner. The clinical and serological discordant results suggest the presence of an immunological deficiency that prevents the formation of HIV-1-specific antibodies.

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Seronegative infection and AIDS caused by an A2 subsubtype HIV-1

Abstract

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